GOALS: To test the hypothesis that obese children are at higher risk of having gastroesophageal reflux symptoms compared with nonobese children. STUDY: In this prospective study, 236 obese children (age: 7 to 16 y) were interviewed using a standard questionnaire for reflux symptoms and a reflux symptom score was calculated. Obesity was defined as body mass index (BMI) greater than 95th percentile for age and sex. One hundred and one age-matched and sex-matched children with BMI between 5th and 95th percentile served as controls. Demographic data were collected in all children. We compared prevalence rates of a reflux symptom score and other symptoms between the 2 groups. RESULTS: A prevalence rate of a positive reflux symptom score (13.1%) was significantly higher in obese children than in the control group (2%) (odds ratio: 7.3, 95% CI: 1.7-31). Obesity remained as the only significant predictor for a positive reflux symptom score after controlling for other variables such as age, sex, race, and caffeine exposure (adjusted odds ratio: 7.4, 95% CI: 1.7-32.5). A positive reflux symptom score increased significantly from 2% in the control group to 11.7% in 196 obese children to 20% in 40 severely obese children (with BMI z-score >2.7). CONCLUSIONS: Obese children (age: 7 to 16 y) are at higher risk of having reflux symptoms compared with the control group. This risk is independent of age, sex, or race and increases with higher BMI.
GOALS: To test the hypothesis that obesechildren are at higher risk of having gastroesophageal reflux symptoms compared with nonobese children. STUDY: In this prospective study, 236 obesechildren (age: 7 to 16 y) were interviewed using a standard questionnaire for reflux symptoms and a reflux symptom score was calculated. Obesity was defined as body mass index (BMI) greater than 95th percentile for age and sex. One hundred and one age-matched and sex-matched children with BMI between 5th and 95th percentile served as controls. Demographic data were collected in all children. We compared prevalence rates of a reflux symptom score and other symptoms between the 2 groups. RESULTS: A prevalence rate of a positive reflux symptom score (13.1%) was significantly higher in obesechildren than in the control group (2%) (odds ratio: 7.3, 95% CI: 1.7-31). Obesity remained as the only significant predictor for a positive reflux symptom score after controlling for other variables such as age, sex, race, and caffeine exposure (adjusted odds ratio: 7.4, 95% CI: 1.7-32.5). A positive reflux symptom score increased significantly from 2% in the control group to 11.7% in 196 obesechildren to 20% in 40 severely obesechildren (with BMI z-score >2.7). CONCLUSIONS:Obesechildren (age: 7 to 16 y) are at higher risk of having reflux symptoms compared with the control group. This risk is independent of age, sex, or race and increases with higher BMI.
Authors: Jessica L Petrick; Scott P Kelly; Linda M Liao; Neal D Freedman; Barry I Graubard; Michael B Cook Journal: Br J Cancer Date: 2017-02-14 Impact factor: 7.640