| Literature DB >> 19097789 |
Wei Shen1, Jae-Seung Kim, Phillip E Kish, Jie Zhang, Stefanie Mitchell, Brian G Gentry, Julie M Breitenbach, John C Drach, John Hilfinger.
Abstract
5'-O-D- and L-amino acid derivatives and 5'-O-(D- and L-amino acid methyl ester phosphoramidate) derivatives of vidarabine (ara-A) were synthesized as vidarabine prodrugs. Some compounds were equi- or more potent in vitro than vidarabine against two pox viruses and their uptake by cultured cells was improved compared to the parent drug.Entities:
Mesh：
Substances：
Year: 2008 PMID： 19097789 PMCID： PMC2642980 DOI： 10.1016/j.bmcl.2008.12.031
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823