Literature DB >> 19095455

Organocatalyzed highly atom economic one pot synthesis of tetrahydropyridines as antimalarials.

Mridul Misra1, Swaroop Kumar Pandey, Vivek Parashar Pandey, Jyoti Pandey, Renu Tripathi, Rama Pati Tripathi.   

Abstract

A highly atom economic one pot synthesis of tetrahydropyridines was achieved by L-proline/TFA catalysed multicomponent reaction of beta-keto-esters, aromatic aldehydes and anilines. The synthesized compounds were screened against Plasmodium falciparum in vitro and one of them showed antimalarial activity with MIC as low as 0.09 microg/mL.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 19095455     DOI： 10.1016/j.bmc.2008.11.062

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  11 in total

Review 1.  Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2009.

Authors:  Roland E Dolle; Bertrand Le Bourdonnec; Karin Worm; Guillermo A Morales; Craig J Thomas; Wei Zhang
Journal:  J Comb Chem       Date:  2010-10-05

2.  VCl3 catalyzed imine-based multicomponent reactions for the facile access of functionalized tetrahydropyridines and β-amino carbonyls.

Authors:  Suman Pal; Lokman Hakim Choudhury; Tasneem Parvin
Journal:  Mol Divers       Date:  2011-11-01       Impact factor: 2.943

3.  Two novel piperidones induce apoptosis and antiproliferative effects on human prostate and lymphoma cancer cell lines.

Authors:  Risa Mia Swain; Lisett Contreras; Armando Varela-Ramirez; Mohammad Hossain; Umashankar Das; Carlos A Valenzuela; Manuel L Penichet; Jonathan R Dimmock; Renato J Aguilera
Journal:  Invest New Drugs       Date:  2022-07-06       Impact factor: 3.651

4.  Robust, highly active, and stable supported Co(ii) nanoparticles on magnetic cellulose nanofiber-functionalized for the multi-component reactions of piperidines and alcohol oxidation.

Authors:  Pouya Ghamari Kargar; Ghodsieh Bagherzade
Journal:  RSC Adv       Date:  2021-07-01       Impact factor: 4.036

5.  PEG-embedded KBr(3): A recyclable catalyst for multicomponent coupling reaction for the efficient synthesis of functionalized piperidines.

Authors:  Sanny Verma; Suman L Jain; Bir Sain
Journal:  Beilstein J Org Chem       Date:  2011-09-28       Impact factor: 2.883

6.  Methyl 4-(4-fluoro-anilino)-1,2,6-tris-(4-fluoro-phen-yl)-1,2,5,6-tetra-hydro-pyri-dine-3-carboxyl-ate.

Authors:  Sumati Anthal; Goutam Brahmachari; Suvankar Das; Rajni Kant; Vivek K Gupta
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-02-09

7.  Ethyl 2,6-bis-(4-chloro-phen-yl)-4-(4-fluoro-anilino)-1-(4-fluoro-phen-yl)-1,2,5,6-tetra-hydro-pyridine-3-carboxyl-ate.

Authors:  Sumati Anthal; Goutam Brahmachari; Suvankar Das; Rajni Kant; Vivek K Gupta
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-03-09

8.  Tandem dinucleophilic cyclization of cyclohexane-1,3-diones with pyridinium salts.

Authors:  Mostafa Kiamehr; Firouz Matloubi Moghaddam; Satenik Mkrtchyan; Volodymyr Semeniuchenko; Linda Supe; Alexander Villinger; Peter Langer; Viktor O Iaroshenko
Journal:  Beilstein J Org Chem       Date:  2013-06-10       Impact factor: 2.883

9.  Highly functionalized piperidines: Free radical scavenging, anticancer activity, DNA interaction and correlation with biological activity.

Authors:  Suvankar Das; Cristiane J da Silva; Marina de M Silva; Maria Dayanne de A Dantas; Ângelo de Fátima; Ana Lúcia T Góis Ruiz; Cleiton M da Silva; João Ernesto de Carvalho; Josué C C Santos; Isis M Figueiredo; Edeildo F da Silva-Júnior; Thiago M de Aquino; João X de Araújo-Júnior; Goutam Brahmachari; Luzia Valentina Modolo
Journal:  J Adv Res       Date:  2017-10-31       Impact factor: 10.479

10.  Synthesis and Antimalarial Activity of 1,4-Disubstituted Piperidine Derivatives.

Authors:  Rokhyatou Seck; Abdoulaye Gassama; Sandrine Cojean; Christian Cavé
Journal:  Molecules       Date:  2020-01-11       Impact factor: 4.411
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.