| Literature DB >> 19095445 |
Stephen P East1, Clara Bantry White, Oliver Barker, Stephanie Barker, James Bennett, David Brown, E Andrew Boyd, Christopher Brennan, Chandana Chowdhury, Ian Collins, Emmanuelle Convers-Reignier, Brian W Dymock, Rowena Fletcher, David J Haydon, Mihaly Gardiner, Stuart Hatcher, Peter Ingram, Paul Lancett, Paul Mortenson, Konstantinos Papadopoulos, Carol Smee, Helena B Thomaides-Brears, Heather Tye, James Workman, Lloyd G Czaplewski.
Abstract
The synthesis and antibacterial activities of three chemotypes of DNA supercoiling inhibitors based on imidazolo[1,2-a]pyridine and [1,2,4]triazolo[1,5-a]pyridine scaffolds that target the ATPase subunits of DNA gyrase and topoisomerase IV (GyrB/ParE) is reported. The most potent scaffold was selected for optimization leading to a series with potent Gram-positive antibacterial activity and a low resistance frequency.Entities:
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Year: 2008 PMID： 19095445 DOI： 10.1016/j.bmcl.2008.11.102
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823