Literature DB >> 1909530

Is amyloidogenesis during Alzheimer's disease due to an IL-1-/IL-6-mediated 'acute phase response' in the brain?

P Vandenabeele1, W Fiers.   

Abstract

Alzheimer's disease is characterized by the presence of amyloid plaques in the brain, which comprise mainly beta-amyloid peptide and alpha 1-antichymotrypsin. Here, Peter Vandenabeele and Walter Fiers advance the hypothesis that this amyloidogenesis results from an IL-1-/IL-6-mediated acute phase reaction in the brain. They propose possible intracerebral sources of cytokines and acute phase proteins in microglia, astrocytes, neurons and cells of the choroid plexus.

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Year:  1991        PMID： 1909530     DOI： 10.1016/0167-5699(91)90032-O

Source DB:  PubMed          Journal:  Immunol Today        ISSN： 0167-5699


  38 in total

1.  Mechanism of interleukin-1- and tumor necrosis factor alpha-dependent regulation of the alpha 1-antichymotrypsin gene in human astrocytes.

Authors:  T Kordula; M Bugno; R E Rydel; J Travis
Journal:  J Neurosci       Date:  2000-10-15       Impact factor: 6.167

2.  Cytokine production by a human microglial cell line: effects of beta-amyloid and alpha-melanocyte-stimulating hormone.

Authors:  Catharina Lindberg; Erik Hjorth; Claes Post; Bengt Winblad; Marianne Schultzberg
Journal:  Neurotox Res       Date:  2005-11       Impact factor: 3.911

Review 3.  Is there a future for cyclo-oxygenase inhibitors in Alzheimer's disease?

Authors:  Lap Ho; Weiping Qin; Breton S Stetka; Giulio M Pasinetti
Journal:  CNS Drugs       Date:  2006       Impact factor: 5.749

Review 4.  Glucocorticoids in Alzheimer's disease. The story so far.

Authors:  P S Aisen; G M Pasinetti
Journal:  Drugs Aging       Date:  1998-01       Impact factor: 3.923

5.  S100beta induction of the proinflammatory cytokine interleukin-6 in neurons.

Authors:  Y Li; S W Barger; L Liu; R E Mrak; W S Griffin
Journal:  J Neurochem       Date:  2000-01       Impact factor: 5.372

Review 6.  Inflammation and Alzheimer's disease.

Authors:  H Akiyama; S Barger; S Barnum; B Bradt; J Bauer; G M Cole; N R Cooper; P Eikelenboom; M Emmerling; B L Fiebich; C E Finch; S Frautschy; W S Griffin; H Hampel; M Hull; G Landreth; L Lue; R Mrak; I R Mackenzie; P L McGeer; M K O'Banion; J Pachter; G Pasinetti; C Plata-Salaman; J Rogers; R Rydel; Y Shen; W Streit; R Strohmeyer; I Tooyoma; F L Van Muiswinkel; R Veerhuis; D Walker; S Webster; B Wegrzyniak; G Wenk; T Wyss-Coray
Journal:  Neurobiol Aging       Date:  2000 May-Jun       Impact factor: 4.673

7.  Amyloid beta peptide potentiates cytokine secretion by interleukin-1 beta-activated human astrocytoma cells.

Authors:  B D Gitter; L M Cox; R E Rydel; P C May
Journal:  Proc Natl Acad Sci U S A       Date:  1995-11-07       Impact factor: 11.205

8.  Inflammatory processes induce beta-amyloid precursor protein changes in mouse brain.

Authors:  B Brugg; Y L Dubreuil; G Huber; E E Wollman; N Delhaye-Bouchaud; J Mariani
Journal:  Proc Natl Acad Sci U S A       Date:  1995-03-28       Impact factor: 11.205

9.  Association between interleukin-6 gene promoter -572C/G polymorphism and the risk of sporadic Alzheimer's disease.

Authors:  Mei-xia He; Wan-li Yang; Ming-ming Zhang; Ya-jun Lian; Hai-ying Hua; Jin-sheng Zeng; Li-rong Zhang
Journal:  Neurol Sci       Date:  2009-12-03       Impact factor: 3.307

Review 10.  Locus Coeruleus Modulates Neuroinflammation in Parkinsonism and Dementia.

Authors:  Filippo Sean Giorgi; Francesca Biagioni; Alessandro Galgani; Nicola Pavese; Gloria Lazzeri; Francesco Fornai
Journal:  Int J Mol Sci       Date:  2020-11-16       Impact factor: 5.923
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