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Literature DB >> 9467682

Glucocorticoids in Alzheimer's disease. The story so far.

Abstract

The inflammatory hypothesis of Alzheimer's disease states that specific inflammatory mechanisms, including the cytokine-driven acute-phase response, complement activation and microglial activation, contribute to neurodegeneration. If the hypothesis is correct, anti-inflammatory treatment aimed at suppression of these mechanisms could slow the rate of disease progression. Towards this goal, a multicentre trial of prednisone in Alzheimer's disease is under way and pilot studies of other anti-inflammatory regimens are being conducted.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1998 PMID： 9467682 DOI： 10.2165/00002512-199812010-00001

Source DB: PubMed Journal: Drugs Aging ISSN： 1170-229X Impact factor: 3.923

51 in total

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3 in total

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Review 2. Inflammation and Alzheimer's disease.

Authors: H Akiyama; S Barger; S Barnum; B Bradt; J Bauer; G M Cole; N R Cooper; P Eikelenboom; M Emmerling; B L Fiebich; C E Finch; S Frautschy; W S Griffin; H Hampel; M Hull; G Landreth; L Lue; R Mrak; I R Mackenzie; P L McGeer; M K O'Banion; J Pachter; G Pasinetti; C Plata-Salaman; J Rogers; R Rydel; Y Shen; W Streit; R Strohmeyer; I Tooyoma; F L Van Muiswinkel; R Veerhuis; D Walker; S Webster; B Wegrzyniak; G Wenk; T Wyss-Coray
Journal: Neurobiol Aging Date: 2000 May-Jun Impact factor: 4.673

Review 3. The Distinct Role of ADAM17 in APP Proteolysis and Microglial Activation Related to Alzheimer's Disease.

Authors: Meng Qian; Xiaoqiang Shen; Huanhuan Wang
Journal: Cell Mol Neurobiol Date: 2015-06-29 Impact factor: 5.046

3 in total