BACKGROUND: The aim of this study was to analyze the constituents of total and types I and III collagen fibers in the transversalis fascias of patients with indirect inguinal hernias, compared with samples removed from nonherniated cadavers. METHODS: Biopsy samples from 26 patients and 26 cadavers were analyzed. Hematoxylin-eosin and picrosirius staining techniques were used. The images obtained were analyzed using a video morphometric technique to determine the constituents of total collagen and types I and III collagen in the transversalis fascia. The picrosirius-stained tissues were submitted to observation under polarized-light microscopy. RESULTS: The results showed 17.3% less total collagen in patients with hernias compared with the control group (P < .01). Type I collagen in patients with indirect inguinal hernias was 23.7% less than the control group (P < .01), type III collagen was 6.4% less in the controls (P < .01). CONCLUSION: The lower percentages of total collagen and type I collagen in the transversalis fascias of patients with indirect inguinal hernias could be a factor in hernia formation.
BACKGROUND: The aim of this study was to analyze the constituents of total and types I and III collagen fibers in the transversalis fascias of patients with indirect inguinal hernias, compared with samples removed from nonherniated cadavers. METHODS: Biopsy samples from 26 patients and 26 cadavers were analyzed. Hematoxylin-eosin and picrosirius staining techniques were used. The images obtained were analyzed using a video morphometric technique to determine the constituents of total collagen and types I and III collagen in the transversalis fascia. The picrosirius-stained tissues were submitted to observation under polarized-light microscopy. RESULTS: The results showed 17.3% less total collagen in patients with hernias compared with the control group (P < .01). Type I collagen in patients with indirect inguinal hernias was 23.7% less than the control group (P < .01), type III collagen was 6.4% less in the controls (P < .01). CONCLUSION: The lower percentages of total collagen and type I collagen in the transversalis fascias of patients with indirect inguinal hernias could be a factor in hernia formation.
Authors: Nicholas K Larsen; Matthew J Reilly; Finosh G Thankam; Robert J Fitzgibbons; Devendra K Agrawal Journal: Expert Rev Clin Immunol Date: 2019-04-25 Impact factor: 4.473
Authors: Brian M Besch; Karen Curtin; Robert Ritch; R Rand Allingham; Barbara M Wirostko Journal: JAMA Ophthalmol Date: 2018-12-01 Impact factor: 7.389
Authors: Karin Lammers; Sabrina L Lince; Marian A Spath; Léon C L T van Kempen; Jan C M Hendriks; Mark E Vierhout; Kirsten B Kluivers Journal: Int Urogynecol J Date: 2011-08-03 Impact factor: 2.894