Literature DB >> 19093922

Effect of computerized provider order entry with clinical decision support on adverse drug events in the long-term care setting.

Jerry H Gurwitz1, Terry S Field, Paula Rochon, James Judge, Leslie R Harrold, Chaim M Bell, Monica Lee, Kathleen White, Jane LaPrino, Janet Erramuspe-Mainard, Martin DeFlorio, Linda Gavendo, Joann L Baril, George Reed, David W Bates.   

Abstract

OBJECTIVES: To evaluate the efficacy of computerized provider order entry with clinical decision support for preventing adverse drug events in long-term care.
DESIGN: Cluster-randomized controlled trial.
SETTING: Two large long-term care facilities. PATIENTS: One thousand one hundred eighteen long-term care residents of 29 resident care units. INTERVENTION: The 29 resident care units, each with computerized provider order entry, were randomized to having a clinical decision support system (intervention units) or not (control units). MEASUREMENTS: The number of adverse drug events, severity of events, and whether the events were preventable.
RESULTS: Within intervention units, 411 adverse drug events occurred over 3,803 resident-months of observation time; 152 (37.0%) were deemed preventable. Within control units, there were 340 adverse drug events over 3,257 resident-months of observation time; 126 (37.1%) were characterized as preventable. There were 10.8 adverse drug events per 100 resident-months and 4.0 preventable events per 100 resident-months on intervention units. There were 10.4 adverse drug events per 100 resident-months and 3.9 preventable events per 100 resident-months on control units. Comparing intervention and control units, the adjusted rate ratios were 1.06 (95% confidence interval (CI)=0.92-1.23) for all adverse drug events and 1.02 (95% CI=0.81-1.30) for preventable adverse drug events.
CONCLUSION: Computerized provider order entry with decision support did not reduce the adverse drug event rate or preventable adverse drug event rate in the long-term care setting. Alert burden, limited scope of the alerts, and a need to more fully integrate clinical and laboratory information may have affected efficacy.

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Year:  2008        PMID: 19093922     DOI: 10.1111/j.1532-5415.2008.02004.x

Source DB:  PubMed          Journal:  J Am Geriatr Soc        ISSN: 0002-8614            Impact factor:   5.562


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