| Literature DB >> 19091625 |
Tomasz Zemleduch1, Margarita Lianeri, Małgorzata Rydzanicz, Marzena Gajecka, Krzysztof Szyfter, Paweł P Jagodziński.
Abstract
The amino acid substitution Arg72Pro in the TP53 protein has an impact on the biochemical and biological activity of this protein, and is associated with several types of cancers. However, the Arg72Pro polymorphism exhibits inconsistent contribution as a risk factor in various cancer types. Therefore, using PCR-RFLPs, we investigated the distribution of Arg72Pro genotypes and alleles in patients with laryngeal cancer (n=123) and controls (n=300) in Poland. We observed that patients with the Pro/Pro and Arg/Pro TP53 genotypes displayed a 1.755-fold increased risk of laryngeal cancer (95% CI=1.149-2.680, P=0.0099). However, we did not find a significant increase in laryngeal cancer risk for the homozygous Pro/Pro TP53 genotype OR=2.093 (95% CI=1.046-4.192, P=0.0530). This result suggests that the TP53Pro variant may contribute to the risk of laryngeal cancer development in Polish patients.Entities:
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Year: 2008 PMID： 19091625 DOI： 10.1016/j.oraloncology.2008.10.009
Source DB: PubMed Journal: Oral Oncol ISSN： 1368-8375 Impact factor: 5.337