| Literature DB >> 19091558 |
Francis Giraud1, Rémi Guillon, Cédric Logé, Fabrice Pagniez, Carine Picot, Marc Le Borgne, Patrice Le Pape.
Abstract
Continuous efforts on the synthesis and structure-activity relationships (SARs) studies of modified 1-benzylamino-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents, allowed identification of new 1-[(pyridinyl- and piperidinylmethyl)amino] derivatives with MIC(80) values ranging from 1410.0 to 23.0ngmL(-1) on Candidaalbicans. These results confirmed both the importance of pi-pi stacking and hydrogen bonding interactions in the active site of CYP51-C. albicans.Entities:
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Year: 2008 PMID： 19091558 DOI： 10.1016/j.bmcl.2008.11.101
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823