Karin C Söderberg1, Jaakko Kaprio2, Pia K Verkasalo3, Eero Pukkala4, Markku Koskenvuo5, Ellen Lundqvist6, Maria Feychting6. 1. The Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE-171 77 Stockholm, Sweden. Electronic address: Karin.Soderberg@ki.se. 2. Department of Public Health, University of Helsinki, Finland; Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland and The Institute for Molecular Medicine, Helsinki, Finland. 3. Department of Environmental Health, National Public Health Institute, Kuopio, Finland. 4. Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland. 5. Department of Public Health, University of Helsinki, Finland. 6. The Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE-171 77 Stockholm, Sweden.
Abstract
BACKGROUND: Obesity is related to an increased risk of several forms of cancer. However, findings from studies on haematological malignancies are inconsistent. METHODS: We used prospectively collected data from two Swedish twin cohorts and the Finnish Twin Cohort (in total 70,067 persons) to study the effects of overweight and obesity on the development of leukaemia, non-Hodgkin lymphoma, Hodgkin's lymphoma and myeloma. The cohorts were followed from baseline through 2002 (Sweden) and through 2004 (Finland). RESULTS: We found a risk increase of myeloma with a relative risk (RR) of 2.1 (95% confidence interval [CI] 1.1-3.7) among obese persons, a RR of 2.5 (1.0-6.2) for chronic myeloid leukaemia and a RR of 2.7 (0.8-9.6) for acute lymphoblastic leukaemia among overweight persons as compared to normal-weighted ones. CONCLUSIONS: Our results add further evidence suggesting that overweight and obesity may have an impact on some haematological malignancies, in particular myeloma.
BACKGROUND:Obesity is related to an increased risk of several forms of cancer. However, findings from studies on haematological malignancies are inconsistent. METHODS: We used prospectively collected data from two Swedish twin cohorts and the Finnish Twin Cohort (in total 70,067 persons) to study the effects of overweight and obesity on the development of leukaemia, non-Hodgkin lymphoma, Hodgkin's lymphoma and myeloma. The cohorts were followed from baseline through 2002 (Sweden) and through 2004 (Finland). RESULTS: We found a risk increase of myeloma with a relative risk (RR) of 2.1 (95% confidence interval [CI] 1.1-3.7) among obesepersons, a RR of 2.5 (1.0-6.2) for chronic myeloid leukaemia and a RR of 2.7 (0.8-9.6) for acute lymphoblastic leukaemia among overweight persons as compared to normal-weighted ones. CONCLUSIONS: Our results add further evidence suggesting that overweight and obesity may have an impact on some haematological malignancies, in particular myeloma.
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