Literature DB >> 25962811

Non-Hodgkin Lymphoma, Body Mass Index, and Cytokine Polymorphisms: A Pooled Analysis from the InterLymph Consortium.

Eleanor Kane1, Christine F Skibola2, Paige M Bracci3, James R Cerhan4, Laura Costas5, Karin Ekström Smedby6, Elizabeth A Holly3, Marc Maynadié7, Anne J Novak4, Tracy J Lightfoot8, Stephen M Ansell4, Alex G Smith8, Mark Liebow4, Mads Melbye9, Lindsay Morton10, Silvia de Sanjosé5, Susan L Slager4, Sophia S Wang11, Yawei Zhang12, Tongzhang Zheng12, Eve Roman8.   

Abstract

BACKGROUND: Excess adiposity has been associated with lymphomagenesis, possibly mediated by increased cytokine production causing a chronic inflammatory state. The relationship between obesity, cytokine polymorphisms, and selected mature B-cell neoplasms is reported.
METHOD: Data on 4,979 cases and 4,752 controls from nine American/European studies from the InterLymph consortium (1988-2008) were pooled. For diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), joint associations of body mass index (from self-reported height and weight) and 12 polymorphisms in cytokines IL1A (rs1800587), IL1B (rs16944, rs1143627), IL1RN (rs454078), IL2 (rs2069762), IL6 (rs1800795, rs1800797), IL10 (rs1800890, rs1800896), TNF (rs1800629), LTA (rs909253), and CARD15 (rs2066847) were investigated using unconditional logistic regression. BMI-polymorphism interaction effects were estimated using the relative excess risk due to interaction (RERI).
RESULTS: Obesity (BMI ≥ 30 kg/m(2)) was associated with DLBCL risk [OR = 1.33; 95% confidence interval (CI), 1.02-1.73], as was TNF-308GA+AA (OR = 1.24; 95% CI, 1.07-1.44). Together, being obese and TNF-308GA+AA increased DLBCL risk almost 2-fold relative to those of normal weight and TNF-308GG (OR = 1.93; 95% CI, 1.27-2.94), with a RERI of 0.41 (95% CI, -0.05-0.84; Pinteraction = 0.13). For FL and CLL/SLL, no associations with obesity or TNF-308GA+AA, either singly or jointly, were observed. No evidence of interactions between obesity and the other polymorphisms were detected.
CONCLUSIONS: Our results suggest that cytokine polymorphisms do not generally interact with BMI to increase lymphoma risk but obesity and TNF-308GA+AA may interact to increase DLBCL risk. IMPACT: Studies using better measures of adiposity are needed to further investigate the interactions between obesity and TNF-308G>A in the pathogenesis of lymphoma. ©2015 American Association for Cancer Research.

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Year:  2015        PMID： 25962811      PMCID： PMC4490950          DOI： 10.1158/1055-9965.EPI-14-1355

Source DB:  PubMed          Journal:  Cancer Epidemiol Biomarkers Prev        ISSN： 1055-9965            Impact factor:   4.254


  50 in total

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2.  The molecular contribution of TNF-α in the link between obesity and breast cancer.

Authors:  Michael Weichhaus; Iain Broom; Giovanna Bermano
Journal:  Oncol Rep       Date:  2010-12-10       Impact factor: 3.906

3.  Estimation of the relative excess risk due to interaction and associated confidence bounds.

Authors:  David B Richardson; Jay S Kaufman
Journal:  Am J Epidemiol       Date:  2009-02-11       Impact factor: 4.897

4.  Differential misclassification and the assessment of gene-environment interactions in case-control studies.

Authors:  M García-Closas; W D Thompson; J M Robins
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Review 5.  Mechanisms of obesity-induced gastrointestinal neoplasia.

Authors:  José O Alemán; Peter R Holt; Leonardo H Eusebi; Luigi Ricciardiello; Kavish Patidar; Arun J Sanyal
Journal:  Gastroenterology       Date:  2013-12-06       Impact factor: 22.682

6.  Proposed classification of lymphoid neoplasms for epidemiologic research from the Pathology Working Group of the International Lymphoma Epidemiology Consortium (InterLymph).

Authors:  Lindsay M Morton; Jennifer J Turner; James R Cerhan; Martha S Linet; Patrick A Treseler; Christina A Clarke; Andrew Jack; Wendy Cozen; Marc Maynadié; John J Spinelli; Adele Seniori Costantini; Thomas Rüdiger; Aldo Scarpa; Tongzhang Zheng; Dennis D Weisenburger
Journal:  Blood       Date:  2007-03-27       Impact factor: 22.113

7.  Non-Hodgkin lymphoma and obesity: a pooled analysis from the InterLymph Consortium.

Authors:  Eleanor V Willett; Lindsay M Morton; Patricia Hartge; Nikolaus Becker; Leslie Bernstein; Paolo Boffetta; Paige Bracci; James Cerhan; Brian C-H Chiu; Pierluigi Cocco; Luigino Dal Maso; Scott Davis; Silvia De Sanjose; Karin Ekstrom Smedby; Maria Grazia Ennas; Lenka Foretova; Elizabeth A Holly; Carlo La Vecchia; Keitaro Matsuo; Marc Maynadie; Mads Melbye; Eva Negri; Alexandra Nieters; Richard Severson; Susan L Slager; John J Spinelli; Anthony Staines; Renato Talamini; Martine Vornanen; Dennis D Weisenburger; Eve Roman
Journal:  Int J Cancer       Date:  2008-05-01       Impact factor: 7.396

8.  Tobacco and alcohol consumption and the risk of non-Hodgkin lymphoma.

Authors:  Eleanor V Willett; Alexandra G Smith; Gareth J Dovey; Gareth J Morgan; Jan Parker; Eve Roman
Journal:  Cancer Causes Control       Date:  2004-10       Impact factor: 2.506

9.  Overweight and obesity at different times in life as risk factors for non-Hodgkin's lymphoma: the multiethnic cohort.

Authors:  Gertraud Maskarinec; Eva Erber; Jasmeet Gill; Wendy Cozen; Laurence N Kolonel
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2008-01-09       Impact factor: 4.254

10.  Anthropometric characteristics and non-Hodgkin's lymphoma and multiple myeloma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC).

Authors:  Julie A Britton; Aneire E Khan; Sabine Rohrmann; Nikolaus Becker; Jakob Linseisen; Alexandra Nieters; Rudolf Kaaks; Anne Tjønneland; Jytte Halkjaer; Marianne Tang Severinsen; Kim Overvad; Tobias Pischon; Heiner Boeing; Antonia Trichopoulou; Victoria Kalapothaki; Dimitrios Trichopoulos; Amalia Mattiello; Giovanna Tagliabue; Carlotta Sacerdote; Petra H M Peeters; H Bas Bueno-de-Mesquita; Eva Ardanaz; Carmen Navarro; Paula Jakszyn; Jone M Altzibar; Göran Hallmans; Beatrice Malmer; Göran Berglund; Jonas Manjer; Naomi Allen; Timothy Key; Sheila Bingham; Hervé Besson; Pietro Ferrari; Mazda Jenab; Paolo Boffetta; Paolo Vineis; Elio Riboli
Journal:  Haematologica       Date:  2008-10-02       Impact factor: 9.941
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Journal:  Leuk Lymphoma       Date:  2021-06-14

2.  Infectious mononucleosis, immune genotypes, and non-Hodgkin lymphoma (NHL): an InterLymph Consortium study.

Authors:  Niquelle Brown Wadé; Cindy M Chang; David Conti; Joshua Millstein; Christine Skibola; Alexandra Nieters; Sophia S Wang; Silvia De Sanjose; Eleanor Kane; John J Spinelli; Paige Bracci; Yawei Zhang; Susan Slager; Jun Wang; Henrik Hjalgrim; Karin Ekstrom Smedby; Elizabeth E Brown; Ruth F Jarrett; Wendy Cozen
Journal:  Cancer Causes Control       Date:  2020-03-02       Impact factor: 2.532

3.  Clinicopathological characteristics and treatment outcome in obese patients with diffuse large B-cell lymphoma.

Authors:  Yu-Ying Wu; Jie-Yu You; Cih-En Huang; Chia-Chen Hsu; Yi-Yang Chen; Hsing-Yi Tsou; Ying-Ju Chen; Chian-Pei Li; Yi-Hua Lai; Chang-Hsien Lu; Ping-Tsung Chen; Chih-Cheng Chen
Journal:  Transl Cancer Res       Date:  2020-10       Impact factor: 1.241
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