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Literature DB >> 19088736

A new function for the RNA-editing enzyme ADAR1.

Abstract

ADAR1 catalyzes the deamination of adenosine to inosine in double-stranded RNA. This RNA-editing enzyme is now shown to be involved in hematopoiesis, where it acts to suppress interferon signaling and to block premature apoptosis.

Entities: Chemical Disease Gene Species

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Year: 2009 PMID： 19088736 PMCID： PMC2945685 DOI： 10.1038/ni0109-16

Source DB: PubMed Journal: Nat Immunol ISSN： 1529-2908 Impact factor: 25.606

12 in total

1. Redirection of silencing targets by adenosine-to-inosine editing of miRNAs.

Authors: Yukio Kawahara; Boris Zinshteyn; Praveen Sethupathy; Hisashi Iizasa; Artemis G Hatzigeorgiou; Kazuko Nishikura
Journal: Science Date: 2007-02-23 Impact factor: 47.728

2. ADAR1 interacts with NF90 through double-stranded RNA and regulates NF90-mediated gene expression independently of RNA editing.

Authors: Yongzhan Nie; Li Ding; Peter N Kao; Robert Braun; Jing-Hua Yang
Journal: Mol Cell Biol Date: 2005-08 Impact factor: 4.272

Review 3. Editor meets silencer: crosstalk between RNA editing and RNA interference.

Authors: Kazuko Nishikura
Journal: Nat Rev Mol Cell Biol Date: 2006-12 Impact factor: 94.444

4. Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules.

Authors: Zhichao Wang; Myoung Kwon Choi; Tatsuma Ban; Hideyuki Yanai; Hideo Negishi; Yan Lu; Tomohiko Tamura; Akinori Takaoka; Kazuko Nishikura; Tadatsugu Taniguchi
Journal: Proc Natl Acad Sci U S A Date: 2008-03-28 Impact factor: 11.205

5. Liver disintegration in the mouse embryo caused by deficiency in the RNA-editing enzyme ADAR1.

Authors: Jochen C Hartner; Carolin Schmittwolf; Andreas Kispert; Albrecht M Müller; Miyoko Higuchi; Peter H Seeburg
Journal: J Biol Chem Date: 2003-11-12 Impact factor: 5.157

6. Stress-induced apoptosis associated with null mutation of ADAR1 RNA editing deaminase gene.

Authors: Qingde Wang; Mana Miyakoda; Weidong Yang; Jaspal Khillan; David L Stachura; Mitchell J Weiss; Kazuko Nishikura
Journal: J Biol Chem Date: 2003-11-12 Impact factor: 5.157

7. Widespread A-to-I RNA editing of Alu-containing mRNAs in the human transcriptome.

Authors: Alekos Athanasiadis; Alexander Rich; Stefan Maas
Journal: PLoS Biol Date: 2004-11-09 Impact factor: 8.029

8. Systematic identification of abundant A-to-I editing sites in the human transcriptome.

Authors: Erez Y Levanon; Eli Eisenberg; Rodrigo Yelin; Sergey Nemzer; Martina Hallegger; Ronen Shemesh; Zipora Y Fligelman; Avi Shoshan; Sarah R Pollock; Dan Sztybel; Moshe Olshansky; Gideon Rechavi; Michael F Jantsch
Journal: Nat Biotechnol Date: 2004-07-18 Impact factor: 54.908

9. Hematopoiesis: an evolving paradigm for stem cell biology.

Authors: Stuart H Orkin; Leonard I Zon
Journal: Cell Date: 2008-02-22 Impact factor: 41.582

10. ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling.

Authors: Jochen C Hartner; Carl R Walkley; Jun Lu; Stuart H Orkin
Journal: Nat Immunol Date: 2008-12-07 Impact factor: 25.606

11 in total

1. ADAR1 deaminase contributes to scheduled skeletal myogenesis progression via stage-specific functions.

Authors: C-L Hsieh; H Liu; Y Huang; L Kang; H-W Chen; Y-T Chen; Y-R Wee; S-J Chen; B C-M Tan
Journal: Cell Death Differ Date: 2014-01-17 Impact factor: 15.828

2. RNA-editing enzymes ADAR1 and ADAR2 coordinately regulate the editing and expression of Ctn RNA.

Authors: Aparna Anantharaman; Omid Gholamalamdari; Abid Khan; Je-Hyun Yoon; Michael F Jantsch; Jochen C Hartner; Myriam Gorospe; Supriya G Prasanth; Kannanganattu V Prasanth
Journal: FEBS Lett Date: 2017-08-30 Impact factor: 4.124

3. RNA-specific adenosine deaminase ADAR1 suppresses measles virus-induced apoptosis and activation of protein kinase PKR.

Authors: Ann M Toth; Zhiqun Li; Roberto Cattaneo; Charles E Samuel
Journal: J Biol Chem Date: 2009-08-25 Impact factor: 5.157

4. MicroRNA-mediated loss of ADAR1 in metastatic melanoma promotes tumor growth.

Authors: Yael Nemlich; Eyal Greenberg; Rona Ortenberg; Michal J Besser; Iris Barshack; Jasmine Jacob-Hirsch; Elad Jacoby; Eran Eyal; Ludmila Rivkin; Victor G Prieto; Nitin Chakravarti; Lyn M Duncan; David M Kallenberg; Eitan Galun; Dorothy C Bennett; Ninette Amariglio; Menashe Bar-Eli; Jacob Schachter; Gideon Rechavi; Gal Markel
Journal: J Clin Invest Date: 2013-06 Impact factor: 14.808