OBJECTIVES: We hypothesised that the gross placental measures would be positively associated with childhood growth. METHODS: We analysed data on 23,967 mother-infant pairs enrolled in the Collaborative Perinatal Project. In race-stratified regression models, the main outcomes were birthweight and z-score body-mass index (BMI) at ages 4 and 7. RESULTS: Some placental measures were significantly associated with z-score BMI at age 7: in Blacks, placental weight (beta = 0.0004/g; 95%CI: 0.0001, 0.0008), chorionic plate area (beta = 0.0007; 95%CI: 0.0001, 0.0012) and largest diameter (beta = 0.013; 95%CI: 0.004, 0.026); and in Whites placental weight (beta = 0.0004/g; 95%CI: 0.0001, 0.0003) and largest diameter (Model 3: beta = 0.020; 95%CI: 0.007, 0.032). Tested as group, placental measures significantly predicted z-score BMI at age 7 (all p values < 0.005). CONCLUSIONS: Placental structure independently predicts birthweight and childhood growth. Strategies to improve placental structure might favourably influence birthweight and childhood development.
OBJECTIVES: We hypothesised that the gross placental measures would be positively associated with childhood growth. METHODS: We analysed data on 23,967 mother-infant pairs enrolled in the Collaborative Perinatal Project. In race-stratified regression models, the main outcomes were birthweight and z-score body-mass index (BMI) at ages 4 and 7. RESULTS: Some placental measures were significantly associated with z-score BMI at age 7: in Blacks, placental weight (beta = 0.0004/g; 95%CI: 0.0001, 0.0008), chorionic plate area (beta = 0.0007; 95%CI: 0.0001, 0.0012) and largest diameter (beta = 0.013; 95%CI: 0.004, 0.026); and in Whites placental weight (beta = 0.0004/g; 95%CI: 0.0001, 0.0003) and largest diameter (Model 3: beta = 0.020; 95%CI: 0.007, 0.032). Tested as group, placental measures significantly predicted z-score BMI at age 7 (all p values < 0.005). CONCLUSIONS: Placental structure independently predicts birthweight and childhood growth. Strategies to improve placental structure might favourably influence birthweight and childhood development.
Authors: A Bavdekar; C S Yajnik; C H Fall; S Bapat; A N Pandit; V Deshpande; S Bhave; S D Kellingray; C Joglekar Journal: Diabetes Date: 1999-12 Impact factor: 9.461
Authors: Ipek Oguz; Natalie Yushkevich; Alison Pouch; Baris U Oguz; Jiancong Wang; Shobhana Parameshwaran; James Gee; Paul A Yushkevich; Nadav Schwartz Journal: J Med Imaging (Bellingham) Date: 2020-02-22
Authors: Carolyn M Salafia; Kristen Lyall; Caichen Zhong; Ruchit Shah; Juliette Rando; Bo Park; Theresa Girardi; Cheryl K Walker; Lisa A Croen; M Daniele Fallin; Irva Hertz-Picciotto; Brian K Lee; Rebecca J Schmidt; Heather E Volk; Craig J Newschaffer Journal: BMC Pregnancy Childbirth Date: 2022-06-28 Impact factor: 3.105
Authors: K Michael Hambidge; Carla M Bann; Elizabeth M McClure; Jamie E Westcott; Ana Garcés; Lester Figueroa; Shivaprasad S Goudar; Sangappa M Dhaded; Omrana Pasha; Sumera A Ali; Richard J Derman; Robert L Goldenberg; Marion Koso-Thomas; Manjunath S Somannavar; Veena Herekar; Umber Khan; Nancy F Krebs Journal: Nutrients Date: 2019-10-21 Impact factor: 5.717
Authors: Kristie Huda; Kenneth F Swan; Cecilia T Gambala; Gabriella C Pridjian; Carolyn L Bayer Journal: Ann Biomed Eng Date: 2021-04-28 Impact factor: 3.934