PURPOSE: Quality of life (QOL) should be improved during palliative chemotherapy for end-stage recurrent head and neck cancer. Therefore, we evaluated QOL in head and neck cancer patients during palliative chemotherapy with cisplatin and docetaxel. METHODS: Thirty patients were included in a prospective study between 2003 and 2007. Response, time-to-progression, overall survival, performance, and toxicity were estimated. QOL was assessed using the EORTC QLQ-C30 and the QLQ-H&N35 questionnaires at baseline, and after each chemotherapy cycle. RESULTS: The response rate was 17%. Sixty-three percent had stable disease. The median time-to-progression was 3.5 months. The median overall survival was 9.2 months. The QLQ-C30 score constipation and the QLQ-H&N35 scores swallowing, senses problems, speech problems, coughing, weight gain showed significant improvement. CONCLUSIONS: Only some aspects of QOL are maintained or improved. The QLQ-H&N35 questionnaire seems to be more appropriate to measure QOL, but needs to be improved to account for the peculiarities of modern palliative chemotherapy.
PURPOSE: Quality of life (QOL) should be improved during palliative chemotherapy for end-stage recurrent head and neck cancer. Therefore, we evaluated QOL in head and neck cancerpatients during palliative chemotherapy with cisplatin and docetaxel. METHODS: Thirty patients were included in a prospective study between 2003 and 2007. Response, time-to-progression, overall survival, performance, and toxicity were estimated. QOL was assessed using the EORTC QLQ-C30 and the QLQ-H&N35 questionnaires at baseline, and after each chemotherapy cycle. RESULTS: The response rate was 17%. Sixty-three percent had stable disease. The median time-to-progression was 3.5 months. The median overall survival was 9.2 months. The QLQ-C30 score constipation and the QLQ-H&N35 scores swallowing, senses problems, speech problems, coughing, weight gain showed significant improvement. CONCLUSIONS: Only some aspects of QOL are maintained or improved. The QLQ-H&N35 questionnaire seems to be more appropriate to measure QOL, but needs to be improved to account for the peculiarities of modern palliative chemotherapy.
Authors: A I Dreyfuss; J R Clark; C M Norris; R M Rossi; J W Lucarini; P M Busse; M D Poulin; L Thornhill; R Costello; M R Posner Journal: J Clin Oncol Date: 1996-05 Impact factor: 44.544
Authors: A A Forastiere; B Metch; D E Schuller; J F Ensley; L F Hutchins; P Triozzi; J A Kish; S McClure; E VonFeldt; S K Williamson Journal: J Clin Oncol Date: 1992-08 Impact factor: 44.544
Authors: K Bjordal; A de Graeff; P M Fayers; E Hammerlid; C van Pottelsberghe; D Curran; M Ahlner-Elmqvist; E J Maher; J W Meyza; A Brédart; A L Söderholm; J J Arraras; J S Feine; H Abendstein; R P Morton; T Pignon; P Huguenin; A Bottomly; S Kaasa Journal: Eur J Cancer Date: 2000-09 Impact factor: 9.162
Authors: K Bjordal; M Ahlner-Elmqvist; E Hammerlid; M Boysen; J F Evensen; A Biörklund; M Jannert; T Westin; S Kaasa Journal: Laryngoscope Date: 2001-08 Impact factor: 3.325
Authors: W Yeo; F K F Mo; J Koh; A T C Chan; T Leung; P Hui; L Chan; A Tang; J J Lee; T S K Mok; P B S Lai; P J Johnson; B Zee Journal: Ann Oncol Date: 2006-04-06 Impact factor: 32.976
Authors: Carrie A Karvonen-Gutierrez; David L Ronis; Karen E Fowler; Jeffrey E Terrell; Stephen B Gruber; Sonia A Duffy Journal: J Clin Oncol Date: 2008-06-01 Impact factor: 44.544
Authors: B Mayrbäurl; L M Wintner; J M Giesinger; Th Himmelfreundpointner; S Burgstaller; B Holzner; J Thaler Journal: Support Care Cancer Date: 2011-12-29 Impact factor: 3.603