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Literature DB >> 19084558

Validation of BKV large T-antigen ATP-binding site as a target for drug discovery.

Gang Zeng¹, Marta Bueno, Carlos J Camachos, Bala Ramaswami, Chunqing Luo, Parmjeet Randhawa.

Abstract

BK virus large T antigen (LTA) is a hexameric protein with a helicase activity that is powered by ATP hydrolysis. A mutant virus with Lys420Ala, Arg421Ala, and Asp504Ala mutations at the ATP binding sites showed marked reduction in viral fitness. This observation indicates that high throughput screening for ATPase inhibitors will be valid strategy to discover anti-BKV drugs. Pilot screening of 300 compounds from the Tim Tec ActiTarg K library identified a compound, STO18584, with selectivity index of 19.2.

Entities: Chemical Disease Gene Species

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Year: 2008 PMID： 19084558 PMCID： PMC2655353 DOI： 10.1016/j.antiviral.2008.11.004

Source DB: PubMed Journal: Antiviral Res ISSN： 0166-3542 Impact factor: 5.970

28 in total

1. Large T antigen on the simian virus 40 origin of replication: a 3D snapshot prior to DNA replication.

Authors: Maria G Gomez-Lorenzo; Mikel Valle; Joachim Frank; Claudia Gruss; Carlos Oscar S Sorzano; Xiaojiang S Chen; Luis Enrique Donate; Jose Maria Carazo
Journal: EMBO J Date: 2003-12-01 Impact factor: 11.598

2. The first case of JC virus allograft nephropathy.

Authors: Amir Kazory; Didier Ducloux; Jean-Marc Chalopin; Régis Angonin; Bernard Fontanière; Hélène Moret
Journal: Transplantation Date: 2003-12-15 Impact factor: 4.939

3. Multiple sequence alignment with the Clustal series of programs.

Authors: Ramu Chenna; Hideaki Sugawara; Tadashi Koike; Rodrigo Lopez; Toby J Gibson; Desmond G Higgins; Julie D Thompson
Journal: Nucleic Acids Res Date: 2003-07-01 Impact factor: 16.971

4. Insights into the oligomeric states, conformational changes, and helicase activities of SV40 large tumor antigen.

Authors: Dahai Gai; Dawei Li; Carla V Finkielstein; Robert D Ott; Poonam Taneja; Ellen Fanning; Xiaojiang S Chen
Journal: J Biol Chem Date: 2004-07-09 Impact factor: 5.157

Review 5. Protein sequence databases.

Authors: Rolf Apweiler; Amos Bairoch; Cathy H Wu
Journal: Curr Opin Chem Biol Date: 2004-02 Impact factor: 8.822

1. Reining in polyoma virus associated nephropathy: design and characterization of a template mimicking BK viral coat protein cellular binding.

Authors: Christopher O Audu; Bethany O'Hara; Maria Pellegrini; Lei Wang; Walter J Atwood; Dale F Mierke
Journal: Biochemistry Date: 2012-10-02 Impact factor: 3.162

1 in total

Validation of BKV large T-antigen ATP-binding site as a target for drug discovery.

1. Large T antigen on the simian virus 40 origin of replication: a 3D snapshot prior to DNA replication.

2. The first case of JC virus allograft nephropathy.

3. Multiple sequence alignment with the Clustal series of programs.

4. Insights into the oligomeric states, conformational changes, and helicase activities of SV40 large tumor antigen.

Review 5. Protein sequence databases.

6. Association between simian virus 40 and non-Hodgkin lymphoma.

7. Polyomavirus simian virus 40 infection associated with nephropathy in a lung-transplant recipient.

8. Structure of the replicative helicase of the oncoprotein SV40 large tumour antigen.

9. The cap region of topoisomerase I binds to sites near both ends of simian virus 40 T antigen.

Review 10. Increasing evidence for involvement of SV40 in human cancer.

1. Reining in polyoma virus associated nephropathy: design and characterization of a template mimicking BK viral coat protein cellular binding.