Adrian Boswood1, Amy Murphy. 1. The Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire AL9 7TA, UK.
Abstract
OBJECTIVES: To evaluate the influence of heart disease and heart failure on 9 parameters: the serum sodium, potassium, chloride, creatinine and urea concentrations, heart rate, vaso-vagal tonus index (VVTI), red cell number and hematocrit. BACKGROUND: Previous studies have demonstrated that heart disease, heart failure and their treatment are associated with changes in laboratory and electrocardiographic parameters. ANIMALS, MATERIALS AND METHODS: Data were retrieved from 92 client-owned dogs with naturally occurring heart disease. Dogs were classified according to the severity of their heart disease and or the presence of heart failure. The effects of heart disease, the progression into heart failure, the initiation of successful therapy and the administration of diuretics on these parameters were determined. RESULTS: Worse heart failure was characterized by the following changes: a significant fall in serum sodium and chloride concentrations and VVTI, and a significant increase in the serum urea concentration and heart rate. The onset of heart failure was characterized by a fall in VVTI and chloride concentration. The successful treatment of heart failure was characterized by a fall in heart rate, an increase in creatinine and sodium concentrations. Dogs receiving diuretics had higher heart rates, lower VVTI, higher urea concentrations, lower potassium, sodium and chloride concentrations. CONCLUSIONS: Numerous complex alterations in some of the studied parameters are associated with heart disease, heart failure and their treatment. Further consideration of these changes may improve our skills in diagnosis, prognostication and treatment.
OBJECTIVES: To evaluate the influence of heart disease and heart failure on 9 parameters: the serum sodium, potassium, chloride, creatinine and urea concentrations, heart rate, vaso-vagal tonus index (VVTI), red cell number and hematocrit. BACKGROUND: Previous studies have demonstrated that heart disease, heart failure and their treatment are associated with changes in laboratory and electrocardiographic parameters. ANIMALS, MATERIALS AND METHODS: Data were retrieved from 92 client-owned dogs with naturally occurring heart disease. Dogs were classified according to the severity of their heart disease and or the presence of heart failure. The effects of heart disease, the progression into heart failure, the initiation of successful therapy and the administration of diuretics on these parameters were determined. RESULTS: Worse heart failure was characterized by the following changes: a significant fall in serum sodium and chloride concentrations and VVTI, and a significant increase in the serum urea concentration and heart rate. The onset of heart failure was characterized by a fall in VVTI and chloride concentration. The successful treatment of heart failure was characterized by a fall in heart rate, an increase in creatinine and sodium concentrations. Dogs receiving diuretics had higher heart rates, lower VVTI, higher urea concentrations, lower potassium, sodium and chloride concentrations. CONCLUSIONS: Numerous complex alterations in some of the studied parameters are associated with heart disease, heart failure and their treatment. Further consideration of these changes may improve our skills in diagnosis, prognostication and treatment.
Authors: J López-Alvarez; J Elliott; D Pfeiffer; Y-M Chang; M Mattin; W Moonarmart; M J Hezzell; A Boswood Journal: J Vet Intern Med Date: 2015 Mar-Apr Impact factor: 3.333
Authors: E Martinelli; C Locatelli; S Bassis; S Crosara; S Paltrinieri; P Scarpa; I Spalla; A M Zanaboni; C Quintavalla; P Brambilla Journal: J Vet Intern Med Date: 2016-09 Impact factor: 3.333