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Literature DB >> 19082568

[Sugammadex. New pharmacological concept for antagonizing rocuronium and vecuronium].

Abstract

Up to now only acetylcholine esterase inhibitors, such as neostigmine, were available as antagonists of residual neuromuscular blocks. Sugammadex is a modified gamma-cyclodextrin that binds rocuronium and chemically similar aminosteroidal muscle relaxants, such as vecuronium. The underlying mechanism of action is new and differs completely from that of acetylcholine esterase inhibitors. This review summarizes data published so far within the framework of the licensing procedure about the efficacy, safety and side-effects of sugammadex and presents potential new anesthesiological concepts using this compound.

Entities: Chemical

Mesh：

Substances：

Year: 2009 PMID： 19082568 DOI： 10.1007/s00101-008-1455-2

Source DB: PubMed Journal: Anaesthesist ISSN： 0003-2417 Impact factor: 1.041

46 in total

1. Acceleromyography vs. electromyography: an ipsilateral comparison of the indirectly evoked neuromuscular response to train-of-four stimulation.

Authors: A F Kopman; W Chin; J Cyriac
Journal: Acta Anaesthesiol Scand Date: 2005-03 Impact factor: 2.105

2. Sugammadex: a revolutionary approach to neuromuscular antagonism.

Authors: Aaron F Kopman
Journal: Anesthesiology Date: 2006-04 Impact factor: 7.892

3. Good clinical research practice in pharmacodynamic studies of neuromuscular blocking agents II: the Stockholm revision.

Authors: T Fuchs-Buder; C Claudius; L T Skovgaard; L I Eriksson; R K Mirakhur; J Viby-Mogensen
Journal: Acta Anaesthesiol Scand Date: 2007-08 Impact factor: 2.105

4. First human exposure of Org 25969, a novel agent to reverse the action of rocuronium bromide.

Authors: Francois Gijsenbergh; Steven Ramael; Natalie Houwing; Thijs van Iersel
Journal: Anesthesiology Date: 2005-10 Impact factor: 7.892

5. Effective reversal of moderate rocuronium- or vecuronium-induced neuromuscular block with sugammadex, a selective relaxant binding agent.

Authors: Koen Suy; Karl Morias; Guy Cammu; Pol Hans; Wilbert G F van Duijnhoven; Marten Heeringa; Ignace Demeyer
Journal: Anesthesiology Date: 2007-02 Impact factor: 7.892

6. Sugammadex reversal of rocuronium-induced neuromuscular blockade: a comparison with neostigmine-glycopyrrolate and edrophonium-atropine.

Authors: Ozlem Sacan; Paul F White; Burcu Tufanogullari; Kevin Klein
Journal: Anesth Analg Date: 2007-03 Impact factor: 5.108

[Sugammadex. New pharmacological concept for antagonizing rocuronium and vecuronium].

1. Acceleromyography vs. electromyography: an ipsilateral comparison of the indirectly evoked neuromuscular response to train-of-four stimulation.

2. Sugammadex: a revolutionary approach to neuromuscular antagonism.

3. Good clinical research practice in pharmacodynamic studies of neuromuscular blocking agents II: the Stockholm revision.

4. First human exposure of Org 25969, a novel agent to reverse the action of rocuronium bromide.

5. Effective reversal of moderate rocuronium- or vecuronium-induced neuromuscular block with sugammadex, a selective relaxant binding agent.

6. Sugammadex reversal of rocuronium-induced neuromuscular blockade: a comparison with neostigmine-glycopyrrolate and edrophonium-atropine.

7. Early and late reversibility of rocuronium bromide.

8. Sugammadex, a new reversal agent for neuromuscular block induced by rocuronium in the anaesthetized Rhesus monkey.

9. Predictive value of mechanomyography and accelerometry for pulmonary function in partially paralyzed volunteers.

10. Simulation of the reversal of neuromuscular block by sequestration of the free molecules of the muscle relaxant.

Review 1. [Implantation of cardioverter-defibrillators. How much anesthesia is necessary?].

Review 2. [Update on muscle relaxation : What comes after succinylcholine, rocuronium and sugammadex?]