| Literature DB >> 19081939 |
Matthew J Belousoff1, Bim Graham, Leone Spiccia, Yitzhak Tor.
Abstract
A number of aminoglycoside antibiotics, and in particular neomycin B, are demonstrated to promote strand cleavage of RNA oligonucleotides (minimised HIV-1 TAR element and prokaryotic ribosomal A-site), by binding and causing sufficient distortion to the RNA backbone to render it more susceptible to intramolecular transesterification.Entities:
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Year: 2008 PMID： 19081939 DOI： 10.1039/b813252f
Source DB: PubMed Journal: Org Biomol Chem ISSN： 1477-0520 Impact factor: 3.876