OBJECTIVE: To demonstrate subacute progression of white matter (WM) injury (4.5mo-2.5y postinjury) in patients with traumatic brain injury using diffusion-tensor imaging. DESIGN: Prospective, repeated-measures, within-subjects design. SETTING: Inpatient neurorehabilitation program and teaching hospital MRI department. PARTICIPANTS: Brain-injured adults (N=13) with a mean Glasgow Coma Scale score of 7.67+/-4.16. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Fractional anisotropy (FA) values were measured at 4.5 and 29 months postinjury in right and left frontal and temporal deep WM tracts and the anterior and posterior corpus callosum. RESULTS: FA significantly decreased in frontal and temporal tracts: right frontal (.38+/-.06 to .30+/-.06; P<.005), left frontal (.37+/-.06 to .32+/-.06; P<.05), right temporal (.28+/-.05 to .22+/-.018; P<.005), and left temporal (.28+/-.05 to .24+/-.02; P<.05). No significant changes were in the corpus callosum. CONCLUSIONS: Preliminary results demonstrate progression of WM damage as evidenced by interval changes in diffusion anisotropy. Future research should examine the relationship between decreased FA and long-term clinical outcome.
OBJECTIVE: To demonstrate subacute progression of white matter (WM) injury (4.5mo-2.5y postinjury) in patients with traumatic brain injury using diffusion-tensor imaging. DESIGN: Prospective, repeated-measures, within-subjects design. SETTING: Inpatient neurorehabilitation program and teaching hospital MRI department. PARTICIPANTS: Brain-injured adults (N=13) with a mean Glasgow Coma Scale score of 7.67+/-4.16. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Fractional anisotropy (FA) values were measured at 4.5 and 29 months postinjury in right and left frontal and temporal deep WM tracts and the anterior and posterior corpus callosum. RESULTS: FA significantly decreased in frontal and temporal tracts: right frontal (.38+/-.06 to .30+/-.06; P<.005), left frontal (.37+/-.06 to .32+/-.06; P<.05), right temporal (.28+/-.05 to .22+/-.018; P<.005), and left temporal (.28+/-.05 to .24+/-.02; P<.05). No significant changes were in the corpus callosum. CONCLUSIONS: Preliminary results demonstrate progression of WM damage as evidenced by interval changes in diffusion anisotropy. Future research should examine the relationship between decreased FA and long-term clinical outcome.
Authors: Elisabeth A Wilde; Marco A Ramos; Ragini Yallampalli; Erin D Bigler; Stephen R McCauley; Zili Chu; Trevor C Wu; Gerri Hanten; Randall S Scheibel; Xiaoqi Li; Ana C Vásquez; Jill V Hunter; Harvey S Levin Journal: Dev Neuropsychol Date: 2010 Impact factor: 2.253
Authors: Brad Kurowski; Shari L Wade; Kim M Cecil; Nicolay C Walz; Weihong Yuan; Akila Rajagopal; Scott K Holland Journal: J Pediatr Rehabil Med Date: 2009
Authors: Stephen R McCauley; Elisabeth A Wilde; Erin D Bigler; Zili Chu; Ragini Yallampalli; Margaret B Oni; Trevor C Wu; Marco A Ramos; Claudia Pedroza; Ana C Vásquez; Jill V Hunter; Harvey S Levin Journal: J Neurotrauma Date: 2011-03-07 Impact factor: 5.269