Literature DB >> 19080744

Molecular profiling of pediatric brain tumors: insight into biology and treatment.

Robert Johnson1, Karen D Wright, Richard J Gilbertson.   

Abstract

Recent history has witnessed unparalleled advances in our understanding of tumor biology, owing in large part to the publication of the human genome project. Paired with improvements in microarray technologies, the combination of genetic and expression profiles provides a unique opportunity to further enhance our understanding of the underlying mechanisms that drive tumor growth. Thus, integrated analysis of identified molecular changes with clinical and histologic data may further delineate a new risk stratification system for pediatric brain tumors, allowing more patient-tailored therapy and molecular-based therapeutic interventions.

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Year:  2009        PMID： 19080744     DOI： 10.1007/s11912-009-0011-9

Source DB:  PubMed          Journal:  Curr Oncol Rep        ISSN： 1523-3790            Impact factor:   5.075


  49 in total

1.  Chromosome arm 6q loss is the most common recurrent autosomal alteration detected in primary pediatric ependymoma.

Authors:  D A Reardon; R E Entrekin; J Sublett; S Ragsdale; H Li; J Boyett; J L Kepner; A T Look
Journal:  Genes Chromosomes Cancer       Date:  1999-03       Impact factor: 5.006

2.  Extensive genomic abnormalities in childhood medulloblastoma by comparative genomic hybridization.

Authors:  D A Reardon; E Michalkiewicz; J M Boyett; J E Sublett; R E Entrekin; S T Ragsdale; M B Valentine; F G Behm; H Li; R L Heideman; L E Kun; D N Shapiro; A T Look
Journal:  Cancer Res       Date:  1997-09-15       Impact factor: 12.701

3.  Epidermal growth factor receptor expression and gene amplification in high-grade non-brainstem gliomas of childhood.

Authors:  M Bredel; I F Pollack; R L Hamilton; C D James
Journal:  Clin Cancer Res       Date:  1999-07       Impact factor: 12.531

4.  Correlation between localization, age, and chromosomal imbalances in ependymal tumours as detected by CGH.

Authors:  Judith W M Jeuken; Sandra H E Sprenger; Job Gilhuis; Hans L J M Teepen; Andre J Grotenhuis; Pieter Wesseling
Journal:  J Pathol       Date:  2002-06       Impact factor: 7.996

Review 5.  The WHO classification of tumors of the nervous system.

Authors:  Paul Kleihues; David N Louis; Bernd W Scheithauer; Lucy B Rorke; Guido Reifenberger; Peter C Burger; Webster K Cavenee
Journal:  J Neuropathol Exp Neurol       Date:  2002-03       Impact factor: 3.685

6.  Outcome of children with centrally reviewed low-grade gliomas treated with chemotherapy with or without radiotherapy on Children's Cancer Group high-grade glioma study CCG-945.

Authors:  Maryam Fouladi; Daniel L Hunt; Ian F Pollack; Gregor Dueckers; Peter C Burger; Laurence E Becker; Allen J Yates; Floyd H Gilles; Richard L Davis; James M Boyett; Jonathan L Finlay
Journal:  Cancer       Date:  2003-09-15       Impact factor: 6.860

7.  High-resolution, dual-platform aCGH analysis reveals frequent HIPK2 amplification and increased expression in pilocytic astrocytomas.

Authors:  H Deshmukh; T H Yeh; J Yu; M K Sharma; A Perry; J R Leonard; M A Watson; D H Gutmann; R Nagarajan
Journal:  Oncogene       Date:  2008-04-14       Impact factor: 9.867

8.  Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome.

Authors:  H Hahn; C Wicking; P G Zaphiropoulous; M R Gailani; S Shanley; A Chidambaram; I Vorechovsky; E Holmberg; A B Unden; S Gillies; K Negus; I Smyth; C Pressman; D J Leffell; B Gerrard; A M Goldstein; M Dean; R Toftgard; G Chenevix-Trench; B Wainwright; A E Bale
Journal:  Cell       Date:  1996-06-14       Impact factor: 41.582

9.  Nonrandom chromosomal gains in pilocytic astrocytomas of childhood.

Authors:  F V White; D C Anthony; E J Yunis; N J Tarbell; R M Scott; D E Schofield
Journal:  Hum Pathol       Date:  1995-09       Impact factor: 3.466

10.  Genetic abnormalities detected in ependymomas by comparative genomic hybridisation.

Authors:  M Carter; J Nicholson; F Ross; J Crolla; R Allibone; V Balaji; R Perry; D Walker; R Gilbertson; D W Ellison
Journal:  Br J Cancer       Date:  2002-03-18       Impact factor: 7.640
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  11 in total

1.  Prognostic significance of histological grading, p53 status, YKL-40 expression, and IDH1 mutations in pediatric high-grade gliomas.

Authors:  Manila Antonelli; Francesca Romana Buttarelli; Antonietta Arcella; Sumihito Nobusawa; Vittoria Donofrio; Hiroko Oghaki; Felice Giangaspero
Journal:  J Neurooncol       Date:  2010-02-21       Impact factor: 4.130

2.  Highly cited publications in pediatric neurosurgery: part 2.

Authors:  Nickalus R Khan; Tyler Auschwitz; Joseph H McAbee; Frederick A Boop; Paul Klimo
Journal:  Childs Nerv Syst       Date:  2013-10-11       Impact factor: 1.475

3.  Lack of efficacy of bevacizumab + irinotecan in cases of pediatric recurrent ependymoma--a Pediatric Brain Tumor Consortium study.

Authors:  Sridharan Gururangan; Jason Fangusaro; Tina Young Poussaint; Arzu Onar-Thomas; Richard J Gilbertson; Sridhar Vajapeyam; Amar Gajjar; Stewart Goldman; Henry S Friedman; Roger J Packer; James M Boyett; Larry E Kun; Roger McLendon
Journal:  Neuro Oncol       Date:  2012-09-26       Impact factor: 12.300

Review 4.  Deep sequencing of coding and non-coding RNA in the CNS.

Authors:  Marcel van der Brug; Michael A Nalls; Mark R Cookson
Journal:  Brain Res       Date:  2010-03-20       Impact factor: 3.252

5.  Pediatric phase II trials of poly-ICLC in the management of newly diagnosed and recurrent brain tumors.

Authors:  Lisa L R Hartman; John R Crawford; Milan T Makale; Mehrzad Milburn; Shweta Joshi; Andres M Salazar; Beth Hasenauer; Scott R VandenBerg; Tobey J MacDonald; Donald L Durden
Journal:  J Pediatr Hematol Oncol       Date:  2014-08       Impact factor: 1.289

6.  Rethinking childhood ependymoma: a retrospective, multi-center analysis reveals poor long-term overall survival.

Authors:  Amanda E Marinoff; Clement Ma; Dongjing Guo; Matija Snuderl; Karen D Wright; Peter E Manley; Hasan Al-Sayegh; Claire E Sinai; Nicole J Ullrich; Karen Marcus; Daphne Haas-Kogan; Liliana Goumnerova; Wendy B London; Mark W Kieran; Susan N Chi; Jason Fangusaro; Pratiti Bandopadhayay
Journal:  J Neurooncol       Date:  2017-07-21       Impact factor: 4.130

Review 7.  Recent Trends of microRNA Significance in Pediatric Population Glioblastoma and Current Knowledge of Micro RNA Function in Glioblastoma Multiforme.

Authors:  Marek Mazurek; Cezary Grochowski; Jakub Litak; Ida Osuchowska; Ryszard Maciejewski; Piotr Kamieniak
Journal:  Int J Mol Sci       Date:  2020-04-27       Impact factor: 5.923

8.  Medulloblastoma exosome proteomics yield functional roles for extracellular vesicles.

Authors:  Laura M Epple; Steve G Griffiths; Anjelika M Dechkovskaia; Nathaniel L Dusto; Jason White; Rodney J Ouellette; Thomas J Anchordoquy; Lynne T Bemis; Michael W Graner
Journal:  PLoS One       Date:  2012-07-27       Impact factor: 3.240

9.  Magnetic resonance spectroscopy metabolite profiles predict survival in paediatric brain tumours.

Authors:  Martin Wilson; Carole L Cummins; Lesley Macpherson; Yu Sun; Kal Natarajan; Richard G Grundy; Theodoros N Arvanitis; Risto A Kauppinen; Andrew C Peet
Journal:  Eur J Cancer       Date:  2012-10-01       Impact factor: 9.162

10.  High-throughput microRNA profiling of pediatric high-grade gliomas.

Authors:  Evelina Miele; Francesca Romana Buttarelli; Antonella Arcella; Federica Begalli; Neha Garg; Marianna Silvano; Agnese Po; Caterina Baldi; Giuseppe Carissimo; Manila Antonelli; Gian Paolo Spinelli; Carlo Capalbo; Vittoria Donofrio; Isabella Morra; Paolo Nozza; Alberto Gulino; Felice Giangaspero; Elisabetta Ferretti
Journal:  Neuro Oncol       Date:  2013-12-04       Impact factor: 12.300
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