PURPOSE: Studies suggest that reduced ocular perfusion pressure in the optic nerve head (ONH) increases the risk of glaucoma. This study tested a hypothesis that the magnitude of blood flow change in the ONH induced between two same intraocular pressure (IOP) alterations depends on the level of mean systemic blood pressure (BP). METHODS: In eight anesthetized rhesus monkeys, systemic BP was maintained at either a high, medium, or low level (n = 6 each, ranging from 51-113 mm Hg); IOP was rapidly altered from 10 to 30 mm Hg and then to 10 mm Hg manometrically. Blood flow in the ONH (BF(ONH)) was repeatedly measured with a laser speckle flow graph for 10 minutes at each IOP level period. The BF(ONH) and relative changes to the baselines at each measured time point were calculated and compared longitudinally among the three BP groups. RESULTS: There was no statistically significant difference in mean baseline BF(ONH) across the BP groups. In the high-BP group, BF(ONH) had no significant change during the IOP alterations. However, the same IOP alterations caused a significant BF(ONH) change in the two lower BP groups. The duration of the BF(ONH) changes from baseline to a peak and to a steady state was significantly delayed in the two lower, but not the higher, BP groups. CONCLUSIONS: Systemic BP plays an important role in maintaining the normal autoregulation of the ONH, and it became deficient in the lower BP groups. In patients with glaucoma, a normal, sustained BP may be important to prevent worsening glaucoma.
PURPOSE: Studies suggest that reduced ocular perfusion pressure in the optic nerve head (ONH) increases the risk of glaucoma. This study tested a hypothesis that the magnitude of blood flow change in the ONH induced between two same intraocular pressure (IOP) alterations depends on the level of mean systemic blood pressure (BP). METHODS: In eight anesthetized rhesus monkeys, systemic BP was maintained at either a high, medium, or low level (n = 6 each, ranging from 51-113 mm Hg); IOP was rapidly altered from 10 to 30 mm Hg and then to 10 mm Hg manometrically. Blood flow in the ONH (BF(ONH)) was repeatedly measured with a laser speckle flow graph for 10 minutes at each IOP level period. The BF(ONH) and relative changes to the baselines at each measured time point were calculated and compared longitudinally among the three BP groups. RESULTS: There was no statistically significant difference in mean baseline BF(ONH) across the BP groups. In the high-BP group, BF(ONH) had no significant change during the IOP alterations. However, the same IOP alterations caused a significant BF(ONH) change in the two lower BP groups. The duration of the BF(ONH) changes from baseline to a peak and to a steady state was significantly delayed in the two lower, but not the higher, BP groups. CONCLUSIONS: Systemic BP plays an important role in maintaining the normal autoregulation of the ONH, and it became deficient in the lower BP groups. In patients with glaucoma, a normal, sustained BP may be important to prevent worsening glaucoma.
Authors: Jingjiang Xu; Yuandong Li; Shaozhen Song; William Cepurna; John Morrison; Ruikang K Wang Journal: Microvasc Res Date: 2018-09-26 Impact factor: 3.514
Authors: Lin Wang; Grant A Cull; Chelsea Piper; Claude F Burgoyne; Brad Fortune Journal: Invest Ophthalmol Vis Sci Date: 2012-12-17 Impact factor: 4.799
Authors: Carla J Abbott; Tiffany E Choe; Theresa A Lusardi; Claude F Burgoyne; Lin Wang; Brad Fortune Journal: Invest Ophthalmol Vis Sci Date: 2014-02-04 Impact factor: 4.799
Authors: Zhongwei Zhi; William Cepurna; Elaine Johnson; Hari Jayaram; John Morrison; Ruikang K Wang Journal: Microvasc Res Date: 2015-07-14 Impact factor: 3.514