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Literature DB >> 19074429

Species-specific inhibition of APOBEC3C by the prototype foamy virus protein bet.

Mario Perkovic¹, Stanislaw Schmidt, Daniela Marino, Rebecca A Russell, Benjamin Stauch, Henning Hofmann, Ferdinand Kopietz, Björn-Philipp Kloke, Jörg Zielonka, Heike Ströver, Johannes Hermle, Dirk Lindemann, Vinay K Pathak, Gisbert Schneider, Martin Löchelt, Klaus Cichutek, Carsten Münk.

Abstract

The APOBEC3 cytidine deaminases are part of the intrinsic defense of cells against retroviruses. Lentiviruses and spumaviruses have evolved essential accessory proteins, Vif and Bet, respectively, which counteract the APOBEC3 proteins. We show here that Bet of the Prototype foamy virus inhibits the antiviral APOBEC3C activity by a mechanism distinct to Vif: Bet forms a complex with APOBEC3C without inducing its degradation. Bet abolished APOBEC3C dimerization as shown by coimmunoprecipitation and cross-linking experiments. These findings implicate a physical interaction between Bet and the APOBEC3C. Subsequently, we identified the Bet interaction domain in human APOBEC3C in the predicted APOBEC3C dimerization site. Taken together, these data support the hypothesis that Bet inhibits incorporation of APOBEC3Cs into retroviral particles. Bet likely achieves this by trapping APOBEC3C protein in complexes rendering them unavailable for newly generated viruses due to direct immobilization.

Entities: Gene Species

Mesh：

Substances：

Year: 2008 PMID： 19074429 PMCID： PMC2645832 DOI： 10.1074/jbc.M808853200

Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157

62 in total

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Journal: Virology Date: 1995-12-20 Impact factor: 3.616

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Journal: J Virol Date: 1999-04 Impact factor: 5.103

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Authors: Claire L Hill; Paul D Bieniasz; Myra O McClure
Journal: J Gen Virol Date: 1999-08 Impact factor: 3.891

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Journal: Virology Date: 1991-09 Impact factor: 3.616

7. Reactivity of primate sera to foamy virus Gag and Bet proteins.

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Journal: J Gen Virol Date: 1994-10 Impact factor: 3.891

8. Aberrant Gag protein composition of a human immunodeficiency virus type 1 vif mutant produced in primary lymphocytes.

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Journal: J Virol Date: 1995-07 Impact factor: 5.103

9. Cells expressing the human foamy virus (HFV) accessory Bet protein are resistant to productive HFV superinfection.

Authors: M Bock; M Heinkelein; D Lindemann; A Rethwilm
Journal: Virology Date: 1998-10-10 Impact factor: 3.616

10. The artiodactyl APOBEC3 innate immune repertoire shows evidence for a multi-functional domain organization that existed in the ancestor of placental mammals.

Authors: Rebecca S LaRue; Stefán R Jónsson; Kevin A T Silverstein; Mathieu Lajoie; Denis Bertrand; Nadia El-Mabrouk; Isidro Hötzel; Valgerdur Andrésdóttir; Timothy P L Smith; Reuben S Harris
Journal: BMC Mol Biol Date: 2008-11-18 Impact factor: 2.946

52 in total

1. Basic residues in the foamy virus Gag protein.

Authors: Daniel Matthes; Tatiana Wiktorowicz; Juliane Zahn; Jochen Bodem; Nicole Stanke; Dirk Lindemann; Axel Rethwilm
Journal: J Virol Date: 2011-02-02 Impact factor: 5.103

2. Feline tetherin efficiently restricts release of feline immunodeficiency virus but not spreading of infection.

Authors: Isabelle Dietrich; Elizabeth L McMonagle; Sarah J Petit; Swetha Vijayakrishnan; Nicola Logan; Chi N Chan; Greg J Towers; Margaret J Hosie; Brian J Willett
Journal: J Virol Date: 2011-04-13 Impact factor: 5.103

3. Simian foamy virus infection of rhesus macaques in Bangladesh: relationship of latent proviruses and transcriptionally active viruses.

Authors: Khanh Soliven; Xiaoxing Wang; Christopher T Small; Mostafa M Feeroz; Eun-Gyung Lee; Karen L Craig; Kamrul Hasan; Gregory A Engel; Lisa Jones-Engel; Frederick A Matsen; Maxine L Linial
Journal: J Virol Date: 2013-10-09 Impact factor: 5.103

4. Feline Immunodeficiency Virus Vif N-Terminal Residues Selectively Counteract Feline APOBEC3s.

Authors: Qinyong Gu; Zeli Zhang; Lucía Cano Ortiz; Ana Cláudia Franco; Dieter Häussinger; Carsten Münk
Journal: J Virol Date: 2016-11-14 Impact factor: 5.103

5. Interaction of Vpx and apolipoprotein B mRNA-editing catalytic polypeptide 3 family member A (APOBEC3A) correlates with efficient lentivirus infection of monocytes.

Authors: André Berger; Carsten Münk; Matthias Schweizer; Klaus Cichutek; Silke Schüle; Egbert Flory
Journal: J Biol Chem Date: 2010-02-23 Impact factor: 5.157

Review 6. Retroviral restriction and dependency factors in primates and carnivores.

Authors: Hind J Fadel; Eric M Poeschla
Journal: Vet Immunol Immunopathol Date: 2011-06-12 Impact factor: 2.046

Review 7. APOBECs and virus restriction.

Authors: Reuben S Harris; Jaquelin P Dudley
Journal: Virology Date: 2015-03-26 Impact factor: 3.616