Literature DB >> 10466797

Properties of human foamy virus relevant to its development as a vector for gene therapy.

Claire L Hill1, Paul D Bieniasz1, Myra O McClure1.   

Abstract

The Spumaviridae (foamy viruses) are increasingly being considered as potential vectors for gene therapy, yet little has been documented of their basic cell biology. This study demonstrates that human foamy virus (HFV) has a broad tropism and that the receptor for HFV is expressed not only on many mammalian, but on avian and reptilian cells. Receptor interference assays using an envelope-expressing cell line and a vesicular stomatitis virus/HFV pseudotype virus demonstrate that the cellular receptor is common to all primate members of the genus. The majority of foamy virus particles assemble and remain sequestered intracellularly. A rapid and quantitative method of assaying foamy virus infectivity by reverse transcriptase activity facilitates the use of classical protocols to increase infectious virus titres in vitro to > or = 10(6) TCID/ml.

Entities:  

Mesh：

Substances：

Year:  1999        PMID： 10466797     DOI： 10.1099/0022-1317-80-8-2003

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


  40 in total

1.  Multiple blocks to human immunodeficiency virus type 1 replication in rodent cells.

Authors:  P D Bieniasz; B R Cullen
Journal:  J Virol       Date:  2000-11       Impact factor: 5.103

2.  Cell cycle requirements for transduction by foamy virus vectors compared to those of oncovirus and lentivirus vectors.

Authors:  Grant Trobridge; David W Russell
Journal:  J Virol       Date:  2004-03       Impact factor: 5.103

3.  Advances in foamy virus vector technology and disease correction could speed the path to clinical application.

Authors:  Els Verhoeyen
Journal:  Mol Ther       Date:  2012-06       Impact factor: 11.454

Review 4.  Molecular biology of foamy viruses.

Authors:  Axel Rethwilm
Journal:  Med Microbiol Immunol       Date:  2010-05-06       Impact factor: 3.402

5.  Novel functions of prototype foamy virus Gag glycine- arginine-rich boxes in reverse transcription and particle morphogenesis.

Authors:  Erik Müllers; Tobias Uhlig; Kristin Stirnnagel; Uwe Fiebig; Hanswalter Zentgraf; Dirk Lindemann
Journal:  J Virol       Date:  2010-11-24       Impact factor: 5.103

6.  Foamy virus vector integration sites in normal human cells.

Authors:  Grant D Trobridge; Daniel G Miller; Michael A Jacobs; James M Allen; Hans-Peter Kiem; Rajinder Kaul; David W Russell
Journal:  Proc Natl Acad Sci U S A       Date:  2006-01-20       Impact factor: 11.205

7.  Correct capsid assembly mediated by a conserved YXXLGL motif in prototype foamy virus Gag is essential for infectivity and reverse transcription of the viral genome.

Authors:  Ingrid Mannigel; Annett Stange; Hanswalter Zentgraf; Dirk Lindemann
Journal:  J Virol       Date:  2007-01-17       Impact factor: 5.103

8.  Restriction of foamy viruses by APOBEC cytidine deaminases.

Authors:  Frédéric Delebecque; Rodolphe Suspène; Sara Calattini; Nicoletta Casartelli; Ali Saïb; Alain Froment; Simon Wain-Hobson; Antoine Gessain; Jean-Pierre Vartanian; Olivier Schwartz
Journal:  J Virol       Date:  2006-01       Impact factor: 5.103

9.  Efficacy of dideoxynucleosides against human foamy virus and relationship to its reverse transcriptase amino acid sequence and structure.

Authors:  A Yvon-Groussin; P Mugnier; P Bertin; M Grandadam; H Agut; J M Huraux; V Calvez
Journal:  J Virol       Date:  2001-08       Impact factor: 5.103

10.  Species-specific inhibition of APOBEC3C by the prototype foamy virus protein bet.

Authors:  Mario Perkovic; Stanislaw Schmidt; Daniela Marino; Rebecca A Russell; Benjamin Stauch; Henning Hofmann; Ferdinand Kopietz; Björn-Philipp Kloke; Jörg Zielonka; Heike Ströver; Johannes Hermle; Dirk Lindemann; Vinay K Pathak; Gisbert Schneider; Martin Löchelt; Klaus Cichutek; Carsten Münk
Journal:  J Biol Chem       Date:  2008-12-12       Impact factor: 5.157
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.