| Literature DB >> 19073174 |
Lili Cao1, Lihui Han, Zhiyong Zhang, Jie Li, Zhonghua Qu, Juan Du, Xiaohong Liang, Yugang Liu, Hua Liu, Yongyu Shi, Suxia Liu, Lifen Gao, Wensheng Sun.
Abstract
Acquisition of anoikis-resistance is a pre-requisite for cancer cell metastasis. We have demonstrated that hepatoma cells could resist anoikis by a synoikis-like survival style. In this study, we further suggest that acquisition of anoikis-resistance confer cancer cells more capacity for invasiveness, evading from cancer therapeutic agents and escaping from host immune attacks. We investigated the response of anoikis-resistant hepatoma cells to TNF-related apoptosis-inducing ligand (TRAIL), a typical immune surveillant molecule as well as a potential anticancer agent. Our data indicated that detached hepatoma cells not only resist TRAIL-induced apoptosis, but also domesticate TRAIL to exert a stealth "tumor counterattack" effect. These results reveal that acquisition of anoikis-resistance may act as a selective pressure to superimpose on hepatoma cells more metastatic potential for the development of cancer.Entities:
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Year: 2008 PMID： 19073174 DOI： 10.1016/j.yexcr.2008.11.010
Source DB: PubMed Journal: Exp Cell Res ISSN： 0014-4827 Impact factor: 3.905