BACKGROUND: The aim of the study was to characterize the distribution of anterior skull base (ASB) cancers in the pediatric population and to identify predictors of outcome. METHODS: This was an international study of 1307 patients undergoing craniofacial surgery for malignant tumors; 6.4% (n = 84) among these were <or=21 years old. RESULTS: The most common histologic type was sarcoma (40%), followed by squamous cell carcinoma (14%). Higher incidence of tumors was found in older children (7.5-21 years) compared to younger children. The 5-year disease-specific and overall survival rates were 61% and 55%, respectively (median follow-up of 30 months). The best prognosis was associated with low-grade sarcomas and the worst with salivary and squamous cell carcinomas. High-grade sarcoma represented an intermediate risk group. On multivariate analysis, prior radiotherapy and histology were independent predictors of survival. CONCLUSION: Surgery for malignant tumors involving the ASB is feasible and safe in children. Histology is significant determinant of poor outcome in this population.
BACKGROUND: The aim of the study was to characterize the distribution of anterior skull base (ASB) cancers in the pediatric population and to identify predictors of outcome. METHODS: This was an international study of 1307 patients undergoing craniofacial surgery for malignant tumors; 6.4% (n = 84) among these were <or=21 years old. RESULTS: The most common histologic type was sarcoma (40%), followed by squamous cell carcinoma (14%). Higher incidence of tumors was found in older children (7.5-21 years) compared to younger children. The 5-year disease-specific and overall survival rates were 61% and 55%, respectively (median follow-up of 30 months). The best prognosis was associated with low-grade sarcomas and the worst with salivary and squamous cell carcinomas. High-grade sarcoma represented an intermediate risk group. On multivariate analysis, prior radiotherapy and histology were independent predictors of survival. CONCLUSION: Surgery for malignant tumors involving the ASB is feasible and safe in children. Histology is significant determinant of poor outcome in this population.
Authors: Irit Duek; Alon Pener-Tessler; Ravit Yanko-Arzi; Arik Zaretski; Avraham Abergel; Ahmad Safadi; Dan M Fliss Journal: J Neurol Surg B Skull Base Date: 2018-01-05
Authors: Gianni Bisogno; Pietro Soloni; Massimo Conte; Marta Podda; Andrea Ferrari; Alberto Garaventa; Roberto Luksch; Giovanni Cecchetto Journal: BMC Cancer Date: 2012-03-25 Impact factor: 4.430
Authors: Vafi Salmasi; Douglas D Reh; Ari M Blitz; Pedram Argani; Masaru Ishii; Gary L Gallia Journal: Childs Nerv Syst Date: 2011-10-29 Impact factor: 1.475
Authors: Abdulaziz AlQahtani; Mario Turri-Zanoni; Iacopo Dallan; Paolo Battaglia; Paolo Castelnuovo Journal: Childs Nerv Syst Date: 2012-08-10 Impact factor: 1.475