BACKGROUND: The aim of this study was to determine whether the aberrant expression of cell-cycle or immune-response markers together with human papillomavirus (HPV) positivity impacts patient survival in different head and neck squamous cell carcinoma (HNSCC) subsets. METHODS: A total of 59 HNSCC specimens were analyzed for expression of cell cycle and proliferation markers, and macrophage infiltration. HPV was evaluated by polymerase chain reaction and DNA sequencing. RESULTS: The HPV presence in oropharynx carcinoma was associated with survival advantage. Low Ki67 expression was associated with favorable outcome in oropharynx and oral cavity carcinoma. A more favorable outcome was associated with low cyclin E expression in larynx carcinoma and with low p53 expression in squamous cell carcinoma (SCC) of the oral cavity. A direct correlation between macrophage infiltration and tumor proliferation index was observed irrespective of the tumor subset. CONCLUSIONS: The assessment of proliferation, viral, and immunologic profiles may be crucial to finding beneficial treatments for the different HNSCC subsets.
BACKGROUND: The aim of this study was to determine whether the aberrant expression of cell-cycle or immune-response markers together with human papillomavirus (HPV) positivity impacts patient survival in different head and neck squamous cell carcinoma (HNSCC) subsets. METHODS: A total of 59 HNSCC specimens were analyzed for expression of cell cycle and proliferation markers, and macrophage infiltration. HPV was evaluated by polymerase chain reaction and DNA sequencing. RESULTS: The HPV presence in oropharynx carcinoma was associated with survival advantage. Low Ki67 expression was associated with favorable outcome in oropharynx and oral cavity carcinoma. A more favorable outcome was associated with low cyclin E expression in larynx carcinoma and with low p53 expression in squamous cell carcinoma (SCC) of the oral cavity. A direct correlation between macrophage infiltration and tumor proliferation index was observed irrespective of the tumor subset. CONCLUSIONS: The assessment of proliferation, viral, and immunologic profiles may be crucial to finding beneficial treatments for the different HNSCC subsets.
Authors: Zipei Feng; Daniel Bethmann; Matthias Kappler; Carmen Ballesteros-Merino; Alexander Eckert; R Bryan Bell; Allen Cheng; Tuan Bui; Rom Leidner; Walter J Urba; Kent Johnson; Clifford Hoyt; Carlo B Bifulco; Juergen Bukur; Claudia Wickenhauser; Barbara Seliger; Bernard A Fox Journal: JCI Insight Date: 2017-07-20
Authors: P Boscolo-Rizzo; A Del Mistro; F Bussu; V Lupato; L Baboci; G Almadori; M C DA Mosto; G Paludetti Journal: Acta Otorhinolaryngol Ital Date: 2013-04 Impact factor: 2.124
Authors: Shay Sharon; Thomas Duhen; Shelly Bambina; Jason Baird; Rom Leidner; Bryan Bell; Nardy Casap; Marka Crittenden; Swetha Vasudevan; Maria Jubran; Nataly Kravchenko-Balasha; Michael Gough Journal: Front Oncol Date: 2021-06-17 Impact factor: 6.244