Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Targeted Paclitaxel by conjugation to iron oxide and gold nanoparticles.

Literature DB >> 19072111

Targeted Paclitaxel by conjugation to iron oxide and gold nanoparticles.

Jih Ru Hwu¹, Yu Sern Lin, Thainashmuthu Josephrajan, Ming-Hua Hsu, Fong-Yu Cheng, Chen-Sheng Yeh, Wu-Chou Su, Dar-Bin Shieh.

Abstract

The Fe(3)O(4) nanoparticles, tailored with maleimidyl 3-succinimidopropionate ligands, were conjugated with paclitaxel molecules that were attached with a poly(ethylene glycol) (PEG) spacer through a phosphodiester moiety at the (C-2')-OH position. The average number of paclitaxel molecules/nanoparticles was determined as 83. These nanoparticles liberated paclitaxel molecules upon exposure to phosphodiesterase.

Entities: Chemical

Mesh：

Substances：

Year: 2009 PMID： 19072111 DOI： 10.1021/ja804947u

Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419

Keyword Cloud
Cited

37 in total

1. An intein-mediated site-specific click conjugation strategy for improved tumor targeting of nanoparticle systems.

Authors: Drew R Elias; Zhiliang Cheng; Andrew Tsourkas
Journal: Small Date: 2010-11-05 Impact factor: 13.281

Review 2. Polymeric materials for theranostic applications.

Authors: Zhe Wang; Gang Niu; Xiaoyuan Chen
Journal: Pharm Res Date: 2013-06-14 Impact factor: 4.200

3. Strategy for increasing drug solubility and efficacy through covalent attachment to polyvalent DNA-nanoparticle conjugates.

Authors: Xue-Qing Zhang; Xiaoyang Xu; Robert Lam; David Giljohann; Dean Ho; Chad A Mirkin
Journal: ACS Nano Date: 2011-08-12 Impact factor: 15.881

Targeted Paclitaxel by conjugation to iron oxide and gold nanoparticles.

1. An intein-mediated site-specific click conjugation strategy for improved tumor targeting of nanoparticle systems.

Review 2. Polymeric materials for theranostic applications.

3. Strategy for increasing drug solubility and efficacy through covalent attachment to polyvalent DNA-nanoparticle conjugates.

4. Photoactivated chemotherapy (PACT): the potential of excited-state d-block metals in medicine.

Review 5. Current Status and Future Direction of Nanomedicine: Focus on Advanced Biological and Medical Applications.

Review 6. Nanoparticles containing insoluble drug for cancer therapy.

7. Mechanism of gold nanoparticles-induced trypsin inhibition: a multi-technique approach.

8. Release kinetics of paclitaxel and cisplatin from two and three layered gold nanoparticles.

Review 9. Monolayer coated gold nanoparticles for delivery applications.

Review 10. Gold nanoparticle platforms as drug and biomacromolecule delivery systems.