Literature DB >> 19070953

Over-expression of the BRMS1 family member SUDS3 does not suppress metastasis of human cancer cells.

Alexandra C Silveira1, Douglas R Hurst, Kedar S Vaidya, Donald E Ayer, Danny R Welch.   

Abstract

BRMS1 and SUDS3 are related members of SIN3-HDAC chromatin remodeling complexes. We hypothesized that they might have overlapping functions and that SUDS3 over-expression could compensate for BRMS1 deficiency. SUDS3 expression was ubiquitous in seven breast cell lines, regardless of metastatic potential. SUDS3 over-expression in BRMS1-non-expressing metastatic cells did not suppress metastasis, motility, osteopontin secretion, or EGF receptor expression, phenotypes associated with BRMS1-mediated metastasis suppression. This study demonstrates functional differences for BRMS1 family members and highlights how the composition of SIN3-HDAC (BRMS1/SUDS3) complexes uniquely affects protein expression and biological behaviors.

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Year:  2008        PMID： 19070953      PMCID： PMC2692985          DOI： 10.1016/j.canlet.2008.10.024

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  49 in total

1.  MCF10DCIS.com xenograft model of human comedo ductal carcinoma in situ.

Authors:  F R Miller; S J Santner; L Tait; P J Dawson
Journal:  J Natl Cancer Inst       Date:  2000-07-19       Impact factor: 13.506

2.  Analysis of mechanisms underlying BRMS1 suppression of metastasis.

Authors:  R S Samant; M J Seraj; M M Saunders; T S Sakamaki; L A Shevde; J F Harms; T O Leonard; S F Goldberg; L Budgeon; W J Meehan; C R Winter; N D Christensen; M F Verderame; H J Donahue; D R Welch
Journal:  Clin Exp Metastasis       Date:  2000       Impact factor: 5.150

3.  Sds3 (suppressor of defective silencing 3) is an integral component of the yeast Sin3[middle dot]Rpd3 histone deacetylase complex and is required for histone deacetylase activity.

Authors:  T Lechner; M J Carrozza; Y Yu; P A Grant; A Eberharter; D Vannier; G Brosch; D J Stillman; D Shore; J L Workman
Journal:  J Biol Chem       Date:  2000-12-29       Impact factor: 5.157

4.  Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex.

Authors:  Leila Alland; Gregory David; Hong Shen-Li; Jason Potes; Rebecca Muhle; Hye-Chun Lee; Harry Hou; Ken Chen; Ronald A DePinho
Journal:  Mol Cell Biol       Date:  2002-04       Impact factor: 4.272

5.  A role for Sds3p, a component of the Rpd3p/Sin3p deacetylase complex, in maintaining cellular integrity in Saccharomyces cerevisiae.

Authors:  D Vannier; P Damay; D Shore
Journal:  Mol Genet Genomics       Date:  2001-05       Impact factor: 3.291

6.  PTEN suppresses breast cancer cell growth by phosphatase activity-dependent G1 arrest followed by cell death.

Authors:  L P Weng; W M Smith; P L Dahia; U Ziebold; E Gil; J A Lees; C Eng
Journal:  Cancer Res       Date:  1999-11-15       Impact factor: 12.701

7.  Malignant MCF10CA1 cell lines derived from premalignant human breast epithelial MCF10AT cells.

Authors:  S J Santner; P J Dawson; L Tait; H D Soule; J Eliason; A N Mohamed; S R Wolman; G H Heppner; F R Miller
Journal:  Breast Cancer Res Treat       Date:  2001-01       Impact factor: 4.872

8.  Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q13.

Authors:  M J Seraj; R S Samant; M F Verderame; D R Welch
Journal:  Cancer Res       Date:  2000-06-01       Impact factor: 12.701

9.  Breast cancer metastatic potential correlates with a breakdown in homospecific and heterospecific gap junctional intercellular communication.

Authors:  M M Saunders; M J Seraj; Z Li; Z Zhou; C R Winter; D R Welch; H J Donahue
Journal:  Cancer Res       Date:  2001-03-01       Impact factor: 12.701

10.  Comedo-ductal carcinoma in situ: A paradoxical role for programmed cell death.

Authors:  Malathy P V Shekhar; Larry Tait; Robert J Pauley; Gen Sheng Wu; Steven J Santner; Pratima Nangia-Makker; Varun Shekhar; Hind Nassar; Daniel W Visscher; Gloria H Heppner; Fred R Miller
Journal:  Cancer Biol Ther       Date:  2008-11-12       Impact factor: 4.742
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  11 in total

1.  Homotypic gap junctional communication associated with metastasis suppression increases with PKA activity and is unaffected by PI3K inhibition.

Authors:  Thomas M Bodenstine; Kedar S Vaidya; Aimen Ismail; Benjamin H Beck; Leah M Cook; Anne R Diers; Aimee Landar; Danny R Welch
Journal:  Cancer Res       Date:  2010-11-23       Impact factor: 12.701

Review 2.  Unraveling the enigmatic complexities of BRMS1-mediated metastasis suppression.

Authors:  Douglas R Hurst; Danny R Welch
Journal:  FEBS Lett       Date:  2011-08-05       Impact factor: 4.124

Review 3.  Metastasis suppressor genes at the interface between the environment and tumor cell growth.

Authors:  Douglas R Hurst; Danny R Welch
Journal:  Int Rev Cell Mol Biol       Date:  2011       Impact factor: 6.813

4.  Structural insights into the assembly of the histone deacetylase-associated Sin3L/Rpd3L corepressor complex.

Authors:  Michael D Clark; Ryan Marcum; Richard Graveline; Clarence W Chan; Tao Xie; Zhonglei Chen; Yujia Ding; Yongbo Zhang; Alfonso Mondragón; Gregory David; Ishwar Radhakrishnan
Journal:  Proc Natl Acad Sci U S A       Date:  2015-06-29       Impact factor: 11.205

5.  A shift from nuclear to cytoplasmic breast cancer metastasis suppressor 1 expression is associated with highly proliferative estrogen receptor-negative breast cancers.

Authors:  Natalya Frolova; Mick D Edmonds; Thomas M Bodenstine; Robert Seitz; Martin R Johnson; Rui Feng; Danny R Welch; Andra R Frost
Journal:  Tumour Biol       Date:  2009-07-16

6.  Linking metastasis suppression with metastamiR regulation.

Authors:  Mick D Edmonds; Douglas R Hurst; Danny R Welch
Journal:  Cell Cycle       Date:  2009-09-23       Impact factor: 4.534

Review 7.  Metastasis suppressor genes.

Authors:  Jinchun Yan; Qin Yang; Qihong Huang
Journal:  Histol Histopathol       Date:  2013-03       Impact factor: 2.303

Review 8.  BRMS1: a multifunctional signaling molecule in metastasis.

Authors:  Rosalyn C Zimmermann; Danny R Welch
Journal:  Cancer Metastasis Rev       Date:  2020-09       Impact factor: 9.264

9.  The C-terminal putative nuclear localization sequence of breast cancer metastasis suppressor 1, BRMS1, is necessary for metastasis suppression.

Authors:  Douglas R Hurst; Yi Xie; John W Thomas; Jianzhong Liu; Mick D Edmonds; Mark D Stewart; Danny R Welch
Journal:  PLoS One       Date:  2013-02-04       Impact factor: 3.240

10.  Breast cancer metastasis suppressor 1 (BRMS1) attenuates TGF-β1-induced breast cancer cell aggressiveness through downregulating HIF-1α expression.

Authors:  Kyung Hwa Cho; Seong-Lan Yu; Do Yeun Cho; Chang Gyo Park; Hoi Young Lee
Journal:  BMC Cancer       Date:  2015-10-31       Impact factor: 4.430
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