Literature DB >> 19066698

Rhabdomyolysis: a case study exploring the possible side effect of lipid lowering medication by a HIV positive patient taking a protease inhibitor.

Diana De Carvalho1, Mark Citro, Anthony Tibbles.   

Abstract

This case study explores the incidence of rhabdomyolysis in a HIV positive patient that was taking a lipid lowering drug and a protease inhibitor concurrently while under chiropractic treatment for generalized muscular soreness. Dyslipidemia is a very common problem both in the general and HIV population, with many patients being prescribed lipid lowering drugs. While extremely rare, adverse effects of lipid lowering drugs have been documented to include myopathy such as rhabdomyolysis. It is imperative that chiropractors are aware of the possible adverse side effect of lipid lowering drug therapy in their patients complaining of musculoskeletal pain. It is even more important that chiropractors treating the HIV population are aware of the potential interactions between these medications and protease inhibitors to cause myopathy.

Entities:  

Keywords:  Drug induced myopathy; HIV infection; lipid lowering drugs; manual therapy; protease inhibitors

Year:  2008        PMID: 19066698      PMCID: PMC2597888     

Source DB:  PubMed          Journal:  J Can Chiropr Assoc        ISSN: 0008-3194


  30 in total

1.  Common problems in the management of hypertriglyceridemia.

Authors:  Michelle A Fung; Jiri J Frohlich
Journal:  CMAJ       Date:  2002-11-26       Impact factor: 8.262

2.  Fenofibrate monotherapy induced rhabdomyolysis.

Authors:  Billie J Barker; Roger R Goodenough; James M Falko
Journal:  Diabetes Care       Date:  2003-08       Impact factor: 19.112

Review 3.  Management of dyslipidemia in diabetes.

Authors:  Maria P Solano; Ronald B Goldberg
Journal:  Cardiol Rev       Date:  2006 May-Jun       Impact factor: 2.644

Review 4.  Micronised fenofibrate: a review of its pharmacodynamic properties and clinical efficacy in the management of dyslipidaemia.

Authors:  J C Adkins; D Faulds
Journal:  Drugs       Date:  1997-10       Impact factor: 9.546

5.  Acute rhabdomyolysis and renal failure in HIV-infected patients: risk factors, presentation, and pathophysiology.

Authors:  M K Joshi; H H Liu
Journal:  AIDS Patient Care STDS       Date:  2000-10       Impact factor: 5.078

Review 6.  Rhabdomyolysis and HMG-CoA reductase inhibitors.

Authors:  M A Omar; J P Wilson; T S Cox
Journal:  Ann Pharmacother       Date:  2001-09       Impact factor: 3.154

7.  HIV protease inhibitors stimulate hepatic triglyceride synthesis.

Authors:  J M Lenhard; D K Croom; J E Weiel; D A Winegar
Journal:  Arterioscler Thromb Vasc Biol       Date:  2000-12       Impact factor: 8.311

8.  Use of complementary and alternative medicine by HIV-infected outpatients in Ontario, Canada.

Authors:  Michelle D Furler; Thomas R Einarson; Sharon Walmsley; Margaret Millson; Reina Bendayan
Journal:  AIDS Patient Care STDS       Date:  2003-04       Impact factor: 5.078

9.  Lipids, lipoproteins, triglyceride clearance, and cytokines in human immunodeficiency virus infection and the acquired immunodeficiency syndrome.

Authors:  C Grunfeld; M Pang; W Doerrler; J K Shigenaga; P Jensen; K R Feingold
Journal:  J Clin Endocrinol Metab       Date:  1992-05       Impact factor: 5.958

10.  A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors.

Authors:  A Carr; K Samaras; S Burton; M Law; J Freund; D J Chisholm; D A Cooper
Journal:  AIDS       Date:  1998-05-07       Impact factor: 4.177

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  2 in total

1.  Statin induced myopathy presenting as mechanical musculoskeletal pain observed in two chiropractic patients.

Authors:  Robert J Rodine; Anthony C Tibbles; Peter Sy Kim; Neetan Alikhan
Journal:  J Can Chiropr Assoc       Date:  2010-03

2.  The prevalence and characteristics of HIV/AIDS patients presenting at a chiropractic outpatient clinic in Toronto, Ontario. A retrospective, observational study.

Authors:  H Stephen Injeyan; Gaelan Connell; Katelyn Foster; Deborah Kopansky-Giles; Guy Sovak; Tony Tibbles
Journal:  J Can Chiropr Assoc       Date:  2018-08
  2 in total

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