Literature DB >> 1906660

HIV-specific humoral and cellular immunity in rabbits vaccinated with recombinant human immunodeficiency virus-like gag-env particles.

O K Haffar1, M D Smithgall, P A Moran, B M Travis, J M Zarling, S L Hu.   

Abstract

Recombinant human immunodeficiency virus type-1 (HIV-1)-like gag-env particles produced in mammalian cells were inoculated into two New Zealand white rabbits. In parallel, two control rabbits were inoculated with the homologous HIV-1 virions inactivated by ultra violet light (uv) and psoralen treatments. The humoral and cellular immune responses to HIV-1 were evaluated for both groups of animals. Recombinant particles elicited humoral immunity that was specific for all the viral structural proteins. The antibodies recognized both denatured and nondenatured proteins. Moreover, the sera neutralized the in vitro infectivity of the homologous virus in CEM cells. Importantly, the recombinant particles also generated a T helper response by priming with the HIV proteins. Similar results were observed with inactivated virus immunization. Therefore, our results suggest that the recombinant HIV-like particles elicit functional humoral immunity as well as cellular immunity and represent a novel vaccine candidate for AIDS.

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Year:  1991        PMID： 1906660     DOI： 10.1016/0042-6822(91)90978-k

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  11 in total

1.  Role of immune responses against the envelope and the core antigens of simian immunodeficiency virus SIVmne in protection against homologous cloned and uncloned virus challenge in Macaques.

Authors:  P S Polacino; V Stallard; J E Klaniecki; S Pennathur; D C Montefiori; A J Langlois; B A Richardson; W R Morton; R E Benveniste; S L Hu
Journal:  J Virol       Date:  1999-10       Impact factor: 5.103

2.  Hybrid human immunodeficiency virus Gag particles as an antigen carrier system: induction of cytotoxic T-cell and humoral responses by a Gag:V3 fusion.

Authors:  J C Griffiths; S J Harris; G T Layton; E L Berrie; T J French; N R Burns; S E Adams; A J Kingsman
Journal:  J Virol       Date:  1993-06       Impact factor: 5.103

3.  HIV-1 Gag p17 presented as virus-like particles on the E2 scaffold from Geobacillus stearothermophilus induces sustained humoral and cellular immune responses in the absence of IFNγ production by CD4+ T cells.

Authors:  Antonella Caivano; Nicole A Doria-Rose; Benjamin Buelow; Rossella Sartorius; Maria Trovato; Luciana D'Apice; Gonzalo J Domingo; William F Sutton; Nancy L Haigwood; Piergiuseppe De Berardinis
Journal:  Virology       Date:  2010-09-20       Impact factor: 3.616

4.  Inhibition of virus production in peripheral blood mononuclear cells from human immunodeficiency virus (HIV) type 1-seropositive donors by treatment with recombinant HIV-like particles.

Authors:  O K Haffar; P A Moran; M D Smithgall; M L Diegel; P Sridhar; J A Ledbetter; J M Zarling; S L Hu
Journal:  J Virol       Date:  1992-07       Impact factor: 5.103

5.  Expression and characterization of genetically engineered human immunodeficiency virus-like particles containing modified envelope glycoproteins: implications for development of a cross-protective AIDS vaccine.

Authors:  B Rovinski; J R Haynes; S X Cao; O James; C Sia; S Zolla-Pazner; T J Matthews; M H Klein
Journal:  J Virol       Date:  1992-07       Impact factor: 5.103

6.  Characterization of human immunodeficiency virus type 1 Pr55gag membrane association in a cell-free system: requirement for a C-terminal domain.

Authors:  E J Platt; O K Haffar
Journal:  Proc Natl Acad Sci U S A       Date:  1994-05-10       Impact factor: 11.205

7.  A human immunodeficiency virus type 1 (HIV-1)-based retroviral vector system utilizing stable HIV-1 packaging cell lines.

Authors:  R Carroll; J T Lin; E J Dacquel; J D Mosca; D S Burke; D C St Louis
Journal:  J Virol       Date:  1994-09       Impact factor: 5.103

8.  A comparative immunogenicity study of HIV-1 virus-like particles bearing various forms of envelope proteins, particles bearing no envelope and soluble monomeric gp120.

Authors:  Emma T Crooks; Penny L Moore; Michael Franti; Charmagne S Cayanan; Ping Zhu; Pengfei Jiang; Robbert P de Vries; Cheryl Wiley; Irina Zharkikh; Norbert Schülke; Kenneth H Roux; David C Montefiori; Dennis R Burton; James M Binley
Journal:  Virology       Date:  2007-06-19       Impact factor: 3.616

9.  Co-immunization with multimeric scaffolds and DNA rapidly induces potent autologous HIV-1 neutralizing antibodies and CD8+ T cells.

Authors:  Juan Pablo Jaworski; Shelly J Krebs; Maria Trovato; Dina N Kovarik; Zachary Brower; William F Sutton; Garrett Waagmeester; Rossella Sartorius; Luciana D'Apice; Antonella Caivano; Nicole A Doria-Rose; Delphine Malherbe; David C Montefiori; Susan Barnett; Piergiuseppe De Berardinis; Nancy L Haigwood
Journal:  PLoS One       Date:  2012-02-16       Impact factor: 3.240

10.  Cross-clade protective immune responses to influenza viruses with H5N1 HA and NA elicited by an influenza virus-like particle.

Authors:  Rick A Bright; Donald M Carter; Corey J Crevar; Franklin R Toapanta; Jonathan D Steckbeck; Kelly S Cole; Niranjan M Kumar; Peter Pushko; Gale Smith; Terrence M Tumpey; Ted M Ross
Journal:  PLoS One       Date:  2008-01-30       Impact factor: 3.240
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