Literature DB >> 19064318

Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ.

Lloyd G Czaplewski1, Ian Collins, E Andrew Boyd, David Brown, Stephen P East, Mihaly Gardiner, Rowena Fletcher, David J Haydon, Vincent Henstock, Peter Ingram, Clare Jones, Caterina Noula, Leanne Kennison, Chris Rockley, Valerie Rose, Helena B Thomaides-Brears, Rebecca Ure, Mark Whittaker, Neil R Stokes.   

Abstract

3-Methoxybenzamide is a weak inhibitor of the essential bacterial cell division protein FtsZ. Exploration of the structure-activity relationships of 3-methoxybenzamide analogues led to the identification of potent anti-staphylococcal compounds.

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Year:  2008        PMID： 19064318     DOI： 10.1016/j.bmcl.2008.11.021

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  33 in total

1.  Chrysophaentins A-H, antibacterial bisdiarylbutene macrocycles that inhibit the bacterial cell division protein FtsZ.

Authors:  Alberto Plaza; Jessica L Keffer; Giuseppe Bifulco; John R Lloyd; Carole A Bewley
Journal:  J Am Chem Soc       Date:  2010-07-07       Impact factor: 15.419

2.  Practical synthesis of PC190723, an inhibitor of the bacterial cell division protein FtsZ.

Authors:  Nohemy A Sorto; Marilyn M Olmstead; Jared T Shaw
Journal:  J Org Chem       Date:  2010-10-29       Impact factor: 4.354

3.  The antibacterial cell division inhibitor PC190723 is an FtsZ polymer-stabilizing agent that induces filament assembly and condensation.

Authors:  José M Andreu; Claudia Schaffner-Barbero; Sonia Huecas; Dulce Alonso; María L Lopez-Rodriguez; Laura B Ruiz-Avila; Rafael Núñez-Ramírez; Oscar Llorca; Antonio J Martín-Galiano
Journal:  J Biol Chem       Date:  2010-03-08       Impact factor: 5.157

4.  Synthesis of (-)-viriditoxin: a 6,6'-binaphthopyran-2-one that targets the bacterial cell division protein FtsZ.

Authors:  Young Sam Park; Charles I Grove; Marcos González-López; Sameer Urgaonkar; James C Fettinger; Jared T Shaw
Journal:  Angew Chem Int Ed Engl       Date:  2011-03-16       Impact factor: 15.336

Review 5.  Challenges of antibacterial discovery.

Authors:  Lynn L Silver
Journal:  Clin Microbiol Rev       Date:  2011-01       Impact factor: 26.132

Review 6.  The rise of fragment-based drug discovery.

Authors:  Christopher W Murray; David C Rees
Journal:  Nat Chem       Date:  2009-06       Impact factor: 24.427

7.  Optimization of thiazole analogues of resveratrol for induction of NAD(P)H:quinone reductase 1 (QR1).

Authors:  Abdelrahman S Mayhoub; Laura Marler; Tamara P Kondratyuk; Eun-Jung Park; John M Pezzuto; Mark Cushman
Journal:  Bioorg Med Chem       Date:  2012-10-23       Impact factor: 3.641

8.  Enterococcal and streptococcal resistance to PC190723 and related compounds: molecular insights from a FtsZ mutational analysis.

Authors:  Malvika Kaul; Yongzheng Zhang; Ajit K Parhi; Edmond J Lavoie; Steve Tuske; Eddy Arnold; John E Kerrigan; Daniel S Pilch
Journal:  Biochimie       Date:  2013-06-25       Impact factor: 4.079

9.  An FtsZ-targeting prodrug with oral antistaphylococcal efficacy in vivo.

Authors:  Malvika Kaul; Lilly Mark; Yongzheng Zhang; Ajit K Parhi; Edmond J Lavoie; Daniel S Pilch
Journal:  Antimicrob Agents Chemother       Date:  2013-09-16       Impact factor: 5.191

10.  Creating an antibacterial with in vivo efficacy: synthesis and characterization of potent inhibitors of the bacterial cell division protein FtsZ with improved pharmaceutical properties.

Authors:  David J Haydon; James M Bennett; David Brown; Ian Collins; Greta Galbraith; Paul Lancett; Rebecca Macdonald; Neil R Stokes; Pramod K Chauhan; Jignesh K Sutariya; Narendra Nayal; Anil Srivastava; Joy Beanland; Robin Hall; Vincent Henstock; Caterina Noula; Chris Rockley; Lloyd Czaplewski
Journal:  J Med Chem       Date:  2010-05-27       Impact factor: 7.446
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