Yaxiao Chen1, Dongzi Yang, Lin Li, Xiaoli Chen. 1. Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
Abstract
BACKGROUND: This study revisited the ovarian volume (OV) as one of the diagnostic criteria for Chinese adolescents with polycystic ovary syndrome (PCOS). It is unknown whether the threshold of 10 cm(3) for the OV, chosen at the PCOS international consensus in 2003, was optimal for Chinese PCOS adolescents or not. METHODS: 69 adolescent PCOS patients and 26 controls were involved in this study. Ultrasound examination was performed between cycle days 2 and 7 or at random with a 6-MHz transvaginal transducer. Receiver operating characteristic (ROC) curves analysis was mainly used for statistical analysis. RESULTS: Mean OV and maximum OV were significantly larger in PCOS group than that in controls. The area under the ROC curve was >0.8 for both criteria, indicating a satisfactory diagnostic potency. The two criteria had no statistical difference in diagnostic potency. Setting the threshold of mean OV at 6.74 cm(3) offered the best compromise between specificity (92.3%) and sensitivity (75.4%) and setting the threshold of maximum OV at 7.82 cm(3) offered the best compromise between specificity (88.5%) and sensitivity (73.9%). CONCLUSIONS: OV yields good diagnostic accuracy to distinguish normal ovaries from polycystic ovaries in Chinese adolescents, but for Chinese PCOS adolescents, the best compromise between sensitivity and specificity was obtained with a threshold set at 6.74 cm(3) for mean ovarian volume and at 7.82 cm(3) for maximum ovarian volume instead of the 10 cm(3) threshold proposed by the Rotterdam consensus conference based on general PCOS patients.
BACKGROUND: This study revisited the ovarian volume (OV) as one of the diagnostic criteria for Chinese adolescents with polycystic ovary syndrome (PCOS). It is unknown whether the threshold of 10 cm(3) for the OV, chosen at the PCOS international consensus in 2003, was optimal for Chinese PCOS adolescents or not. METHODS: 69 adolescent PCOSpatients and 26 controls were involved in this study. Ultrasound examination was performed between cycle days 2 and 7 or at random with a 6-MHz transvaginal transducer. Receiver operating characteristic (ROC) curves analysis was mainly used for statistical analysis. RESULTS: Mean OV and maximum OV were significantly larger in PCOS group than that in controls. The area under the ROC curve was >0.8 for both criteria, indicating a satisfactory diagnostic potency. The two criteria had no statistical difference in diagnostic potency. Setting the threshold of mean OV at 6.74 cm(3) offered the best compromise between specificity (92.3%) and sensitivity (75.4%) and setting the threshold of maximum OV at 7.82 cm(3) offered the best compromise between specificity (88.5%) and sensitivity (73.9%). CONCLUSIONS: OV yields good diagnostic accuracy to distinguish normal ovaries from polycystic ovaries in Chinese adolescents, but for Chinese PCOS adolescents, the best compromise between sensitivity and specificity was obtained with a threshold set at 6.74 cm(3) for mean ovarian volume and at 7.82 cm(3) for maximum ovarian volume instead of the 10 cm(3) threshold proposed by the Rotterdam consensus conference based on general PCOSpatients.
Authors: Lisa E Kenigsberg; Chhavi Agarwal; Sanghun Sin; Keivan Shifteh; Carmen R Isasi; Rebecca Crespi; Janeta Ivanova; Susan M Coupey; Rubina A Heptulla; Raanan Arens Journal: Fertil Steril Date: 2015-09-03 Impact factor: 7.329