OBJECTIVE: To study the chromosomal content of spermatozoa selected by intracytoplasmic morphologically selected sperm injection (IMSI) in cases of macrocephalic sperm head syndrome. DESIGN: Case report. SETTING: Obstetrics, gynecology, urology, and reproductive biology departments. PATIENT(S): Two infertile patients with large-headed spermatozoa. INTERVENTION(S): Fluorescence in situ hybridization on selected spermatozoa with normal-sized heads after IMSI selection. MAIN OUTCOME MEASURE(S): Percentages of polyploid, diploid, haploid aneuploid, and normal spermatozoa. RESULT(S): Of the six spermatozoa that could be selected, all were haploid but aneuploid. CONCLUSION(S): Absence of normal haploid spermatozoa among high magnification-selected spermatozoa contraindicated IMSI for these two patients. Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
OBJECTIVE: To study the chromosomal content of spermatozoa selected by intracytoplasmic morphologically selected sperm injection (IMSI) in cases of macrocephalic sperm head syndrome. DESIGN: Case report. SETTING: Obstetrics, gynecology, urology, and reproductive biology departments. PATIENT(S): Two infertilepatients with large-headed spermatozoa. INTERVENTION(S): Fluorescence in situ hybridization on selected spermatozoa with normal-sized heads after IMSI selection. MAIN OUTCOME MEASURE(S): Percentages of polyploid, diploid, haploid aneuploid, and normal spermatozoa. RESULT(S): Of the six spermatozoa that could be selected, all were haploid but aneuploid. CONCLUSION(S): Absence of normal haploid spermatozoa among high magnification-selected spermatozoa contraindicated IMSI for these two patients. Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.