Bioaccumulation and metabolism of [14C]bisphenol A in the brackish water bivalve Corbicula japonica.

The brackish water bivalve mollusk Corbicula japonica was exposed to brackish water containing approximately 9 microg/l [(14)C]bisphenol A (BPA) for 168 h (the uptake phase), and subsequently transferred to clean brackish water for 144 h (the depuration phase) under semi-static conditions. Mono and disulfate conjugates of BPA were detected in the bivalves as major metabolites. At the end of the uptake phase, the visceral mass contained the highest (14)C-concentration, and the monosulfate conjugate of BPA was a major metabolite in the visceral mass. These data suggest that the visceral mass is the major tissue/organ to take up and metabolize BPA in these bivalves. The BPA concentration in the bivalves readily reached steady state during the uptake phase and immediately decreased in the depuration phase. The accumulation and elimination rates of the mono and disulfate conjugates of BPA were slower than those of BPA.