| Literature DB >> 19059776 |
Andrew G Cole1, Tara M Stauffer, Laura L Rokosz, Axel Metzger, Lawrence W Dillard, Wenguang Zeng, Ian Henderson.
Abstract
The discovery and synthesis of a series of 2-amino-5-benzoyl-4-(2-furyl)thiazoles as adenosine A(2A) receptor antagonists from a small-molecule combinatorial library using a high-throughput radioligand-binding assay is described. Antagonists were further characterized in the A(2A) binding assay and an A(1) selectivity assay. Selected examples exhibited excellent affinity for A(2A) and good selectivity versus the A(1) receptor.Entities:
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Year: 2008 PMID： 19059776 DOI： 10.1016/j.bmcl.2008.11.066
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823