| Literature DB >> 19059704 |
Sebastian Baehs1, Andreas Herbst, Susanne E Thieme, Claudia Perschl, Andrea Behrens, Silvio Scheel, Andreas Jung, Thomas Brabletz, Burkhard Göke, Helmut Blum, Frank T Kolligs.
Abstract
Like Dickkopf-1 (DKK1), DKK4 is a target of beta-catenin/Tcf-4 in colorectal cancer. However, as a negative regulator of Wnt signalling its function in colorectal cancer cells is not well understood. We report that DKK4 is frequently down-regulated in colorectal cancer cell lines with deregulated beta-catenin/Tcf-4 and in primary colorectal cancers. Exposure of cancer cells to DKK4 strongly inhibits basal beta-catenin/Tcf-4 signalling activity, cancer cell growth and cell cycle progression. Therefore, loss of this negative feed-back loop provides Wnt factor expressing cancer cells with a growth advantage. Our data demonstrate that DKK4 is an important negative regulator of colon cancer cell growth.Entities:
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Year: 2008 PMID： 19059704 DOI： 10.1016/j.canlet.2008.11.003
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679