| Literature DB >> 19058971 |
Yanpeng Hou1, Shugeng Cao, Peggy Brodie, Martin Callmander, Fidisoa Ratovoson, Richard Randrianaivo, Etienne Rakotobe, Vincent E Rasamison, Stephan Rakotonandrasana, Karen TenDyke, Edward M Suh, David G I Kingston.
Abstract
Bioassay-guided fractionation of an ethanol extract of a Madagascar collection of Elaeodendron alluaudianum led to the isolation of two new cardenolide glycosides (1 and 2). The (1)H and (13)C NMR spectra of both compounds were fully assigned using a combination of 2D NMR experiments, including (1)H-(1)H COSY, HSQC, HMBC, and ROESY sequences. Both compounds 1 and 2 were tested against the A2780 human ovarian cancer cell line and the U937 human histiocytic lymphoma cell line assays, and showed significant antiproliferative activity with IC(50) values of 0.12 and 0.07 microM against the A2780 human ovarian cancer cell line, and 0.15 and 0.08 microM against the U937 human histiocytic lymphoma cell line, respectively.Entities:
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Year: 2008 PMID： 19058971 PMCID： PMC2860880 DOI： 10.1016/j.bmc.2008.10.092
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641