Literature DB >> 10939358

Cytotoxic cardenolides and antibacterial terpenoids from Crossopetalum gaumeri.

A Ankli1, J Heilmann, M Heinrich, O Sticher.   

Abstract

From the methanol extract of the roots of (Crossopetalum gaumeri, four new highly cytotoxic cardenolides, securigenin-3beta-O-beta-6-deoxyguloside (2), 19-hydroxy-sarmentogenin-3beta-O-beta-6-deoxyguloside (4), sarmentogenin-3beta-O-[alpha-allosyl-(1-->4)-beta-6-deoxy alloside] (5), and securigenin-3beta-O-[alpha-allosyl-(1-->4)-beta-6-deoxyal loside] (6) were isolated. The dichloromethane extract afforded the new diterpene 3,15-dihydroxy-18-norabieta-3,8,11,13-tetraene (7) as well as the new triterpene 2,3,7-trihydroxy-6-oxo-1,3,5(10),7-tetraene-24-nor-friedelane-29-o ic acid methylester (11). The new terpenoids lack cytotoxicity and the antibacterial activity is moderate to low.

Entities:  

Mesh：

Substances：

Year:  2000        PMID： 10939358     DOI： 10.1016/s0031-9422(00)00144-8

Source DB:  PubMed          Journal:  Phytochemistry        ISSN： 0031-9422            Impact factor:   4.072


  7 in total

Review 1.  Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae).

Authors:  Anita M Brinker; Jun Ma; Peter E Lipsky; Ilya Raskin
Journal:  Phytochemistry       Date:  2007-01-23       Impact factor: 4.072

2.  Antiproliferative cardenolides of an Elaeodendron sp. from the Madagascar rain forest(1).

Authors:  Shugeng Cao; Peggy J Brodie; James S Miller; Fidy Ratovoson; Martin W Callmander; Sennen Randrianasolo; Etienne Rakotobe; Vincent E Rasamison; Edward M Suh; Karen TenDyke; David G I Kingston
Journal:  J Nat Prod       Date:  2007-06-05       Impact factor: 4.050

3.  Securigenin glycosides as hypoglycemic principles of Securigera securidaca seeds.

Authors:  Zahra Tofighi; Fahimeh Moradi-Afrapoli; Samad Nejad Ebrahimi; Saied Goodarzi; Abbas Hadjiakhoondi; Markus Neuburger; Matthias Hamburger; Mohammad Abdollahi; Narguess Yassa
Journal:  J Nat Med       Date:  2016-11-15       Impact factor: 2.343

Review 4.  Ethnomedical research and review of Q'eqchi Maya women's reproductive health in the Lake Izabal region of Guatemala: Past, present and future prospects.

Authors:  Joanna L Michel; Armando Caceres; Gail B Mahady
Journal:  J Ethnopharmacol       Date:  2015-12-09       Impact factor: 4.360

5.  Antiproliferative cardenolide glycosides of Elaeodendron alluaudianum from the Madagascar Rainforest.

Authors:  Yanpeng Hou; Shugeng Cao; Peggy Brodie; Martin Callmander; Fidisoa Ratovoson; Richard Randrianaivo; Etienne Rakotobe; Vincent E Rasamison; Stephan Rakotonandrasana; Karen TenDyke; Edward M Suh; David G I Kingston
Journal:  Bioorg Med Chem       Date:  2008-11-13       Impact factor: 3.641

Review 6.  Pentacyclic Triterpenoids Isolated from Celastraceae: A Focus in the 13C-NMR Data.

Authors:  Karen Caroline Camargo; Mariana Guerra de Aguilar; Acácio Raphael Aguiar Moraes; Raquel Goes de Castro; Daiane Szczerbowski; Elizabeth Luciana Marinho Miguel; Leila Renan Oliveira; Grasiely Faria Sousa; Diogo Montes Vidal; Lucienir Pains Duarte
Journal:  Molecules       Date:  2022-01-31       Impact factor: 4.411

Review 7.  Oleandrin: A cardiac glycosides with potent cytotoxicity.

Authors:  Arvind Kumar; Tanmoy De; Amrita Mishra; Arun K Mishra
Journal:  Pharmacogn Rev       Date:  2013-07
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.