OBJECTIVE: The present study aimed to investigate possible association of the apolipoprotein E (APOE) gene polymorphisms with age at natural menopause (ANM) in Caucasian females. DESIGN: Four SNPs (including two replacements, SNP3 Cys112Arg and SNP4 Arg158Cys) were genotyped in 253 randomly selected unrelated Caucasian women having experienced natural menopause. The comprehensive statistical analyses focusing on the association of the APOE gene and some environmental factors with ANM were conducted. RESULTS: Alcohol consumption was a significantly predictor of earlier natural menopause (P<0.05). One SNP (rs769450) was significantly associated with ANM according to both population based and the transmission disequilibrium test (TDT) analyses (P=0.007 and 0.046, respectively). However, no association was observed between APOE varepsilon2, varepsilon3, varepsilon4 and ANM. CONCLUSIONS: Genetic variation in the APOE gene may influence the variation in ANM in Caucasian women.
OBJECTIVE: The present study aimed to investigate possible association of the apolipoprotein E (APOE) gene polymorphisms with age at natural menopause (ANM) in Caucasian females. DESIGN: Four SNPs (including two replacements, SNP3 Cys112Arg and SNP4 Arg158Cys) were genotyped in 253 randomly selected unrelated Caucasian women having experienced natural menopause. The comprehensive statistical analyses focusing on the association of the APOE gene and some environmental factors with ANM were conducted. RESULTS:Alcohol consumption was a significantly predictor of earlier natural menopause (P<0.05). One SNP (rs769450) was significantly associated with ANM according to both population based and the transmission disequilibrium test (TDT) analyses (P=0.007 and 0.046, respectively). However, no association was observed between APOE varepsilon2, varepsilon3, varepsilon4 and ANM. CONCLUSIONS: Genetic variation in the APOE gene may influence the variation in ANM in Caucasian women.
Authors: E C van Beresteijn; J C Korevaar; P C Huijbregts; E G Schouten; J Burema; F J Kok Journal: Am J Epidemiol Date: 1993-02-15 Impact factor: 4.897
Authors: A E Weel; A G Uitterlinden; I C Westendorp; H Burger; S C Schuit; A Hofman; T J Helmerhorst; J P van Leeuwen; H A Pols Journal: J Clin Endocrinol Metab Date: 1999-09 Impact factor: 5.958
Authors: Rafael O Alvim; Silvia R S Freitas; Noely E Ferreira; Paulo C J L Santos; Roberto S Cunha; José G Mill; José E Krieger; Alexandre C Pereira Journal: Lipids Health Dis Date: 2010-11-08 Impact factor: 3.876
Authors: Kylee L Spencer; Jennifer Malinowski; Cara L Carty; Nora Franceschini; Lindsay Fernández-Rhodes; Alicia Young; Iona Cheng; Marylyn D Ritchie; Christopher A Haiman; Lynne Wilkens; Tara C Matise; Christopher S Carlson; Kathleen Brennan; Amy Park; Aleksandar Rajkovic; Lucia A Hindorff; Steven Buyske; Dana C Crawford Journal: PLoS One Date: 2013-02-12 Impact factor: 3.240