Literature DB >> 19056311

Spectroscopic studies on the interaction of hypocrellin A and hemoglobin.

Jiahong Zhou1, Xiaohong Wu, Xiaotian Gu, Lin Zhou, Kaixi Song, Shaohua Wei, Yuying Feng, Jian Shen.   

Abstract

The spectrophotometric and spectrofluorimetric studies revealed that hemoglobin (Hb) could interact with hypocrellin A, a photosensitizing drug used in photodynamic therapy. It was found that this kind of interaction can induce the conformational changes in Hb. In addition, based on fluorescence quenching titration and electron paramagnetic resonance spectroscopy results, the binding parameters, thermodynamic parameters are obtained. The quenching mechanism is also proposed.

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Year:  2008        PMID： 19056311     DOI： 10.1016/j.saa.2008.09.009

Source DB:  PubMed          Journal:  Spectrochim Acta A Mol Biomol Spectrosc        ISSN： 1386-1425            Impact factor:   4.098


  12 in total

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