Literature DB >> 19055376

First total synthesis of hinckdentine A.

Kazuhiro Higuchi1, Yukihiro Sato, Mei Tsuchimochi, Kenta Sugiura, Masatoshi Hatori, Tomomi Kawasaki.   

Abstract

We have accomplished the first total synthesis of (+/-)-hinckdentine A (1). The key steps are m-CPBA oxidation of 2-arylindole followed by acid-mediated Mannich-type C-C bond formation of 2-hydroxyindolin-3-one, seven-membered ring closure, and regioselective tribromination.

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Year:  2009        PMID： 19055376     DOI： 10.1021/ol802394n

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


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