Literature DB >> 190543

Structure of an antibody combining site by magnetic resonance.

R A Dwek, S Wain-Hobson, S Dower, P Gettins, B Sutton, S J Perkins, D Givol.   

Abstract

The structure of the combining site of the DNP binding IgA mouse myeloma protein MOPC 315 has been determined by a combination of high resolution nuclear magnetic resonance, electron spin resonance, model building and chemical modifications. This approach yields that general dimensions of the site, its polarity and asymmetry features, the assignment of the DNP-contact residues and their three-dimensional coordinates.

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Year:  1977        PMID： 190543     DOI： 10.1038/266031a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  8 in total

Review 1.  Biosynthetic antibody binding sites: development of a single-chain Fv model based on antidinitrophenol IgA myeloma MOPC 315.

Authors:  J E McCartney; L Lederman; E A Drier; N A Cabral-Denison; G M Wu; R S Batorsky; J S Huston; H Oppermann
Journal:  J Protein Chem       Date:  1991-12

2.  Cold pepsin digestion: a novel method to produce the Fv fragment from human immunoglobulin M.

Authors:  L C Lin; F W Putnam
Journal:  Proc Natl Acad Sci U S A       Date:  1978-06       Impact factor: 11.205

3.  Sequences of 12 monoclonal anti-dinitrophenyl spin-label antibodies for NMR studies.

Authors:  D J Leahy; G S Rule; M M Whittaker; H M McConnell
Journal:  Proc Natl Acad Sci U S A       Date:  1988-06       Impact factor: 11.205

4.  Proton-n.m.r. study of interaction of myelin basic protein with a monoclonal antibody.

Authors:  G L Mendz; W J Moore; S Easterbrook-Smith; D S Linthicum
Journal:  Biochem J       Date:  1985-05-15       Impact factor: 3.857

5.  Crystallization of the Fv fragment of mouse myeloma protein M315.

Authors:  R Aschaffenburg; D C Phillips; D R Rose; B J Sutton; S K Dower; R A Dwek
Journal:  Biochem J       Date:  1979-08-01       Impact factor: 3.857

6.  Diversity at the variable-joining region boundary of lambda light chains has a pronounced effect on immunoglobulin ligand-binding activity.

Authors:  T Azuma; V Igras; E B Reilly; H N Eisen
Journal:  Proc Natl Acad Sci U S A       Date:  1984-10       Impact factor: 11.205

7.  The binding of 2,4,6-trinitrophenyl derivatives to the mouse myeloma immunoglobulin A protein MOPC 315.

Authors:  S K Dower; P Gettins; R Jackson; R A Dwek; D Givol
Journal:  Biochem J       Date:  1978-01-01       Impact factor: 3.857

8.  Resonance Raman-spectroscopic studies of the hapten features involved in the binding of 2,4-dinitrophenyl haptens by the mouse myeloma proteins MOPC 315 and MOPC 460.

Authors:  K Kumar; D J Phelps; P R Carey; N M Young
Journal:  Biochem J       Date:  1978-11-01       Impact factor: 3.857
  8 in total

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