Literature DB >> 19050712

Perceiving is believing: a Bayesian approach to explaining the positive symptoms of schizophrenia.

Paul C Fletcher1, Chris D Frith.   

Abstract

Advances in cognitive neuroscience offer us new ways to understand the symptoms of mental illness by uniting basic neurochemical and neurophysiological observations with the conscious experiences that characterize these symptoms. Cognitive theories about the positive symptoms of schizophrenia--hallucinations and delusions--have tended to treat perception and belief formation as distinct processes. However, recent advances in computational neuroscience have led us to consider the unusual perceptual experiences of patients and their sometimes bizarre beliefs as part of the same core abnormality--a disturbance in error-dependent updating of inferences and beliefs about the world. We suggest that it is possible to understand these symptoms in terms of a disturbed hierarchical Bayesian framework, without recourse to separate considerations of experience and belief.

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Year:  2008        PMID: 19050712     DOI: 10.1038/nrn2536

Source DB:  PubMed          Journal:  Nat Rev Neurosci        ISSN: 1471-003X            Impact factor:   34.870


  374 in total

1.  Adaptation to conflict via context-driven anticipatory signals in the dorsomedial prefrontal cortex.

Authors:  Guillermo Horga; Tiago V Maia; Pengwei Wang; Zhishun Wang; Rachel Marsh; Bradley S Peterson
Journal:  J Neurosci       Date:  2011-11-09       Impact factor: 6.167

Review 2.  Toward a neurobiology of delusions.

Authors:  P R Corlett; J R Taylor; X-J Wang; P C Fletcher; J H Krystal
Journal:  Prog Neurobiol       Date:  2010-06-15       Impact factor: 11.685

Review 3.  Update on memory systems and processes.

Authors:  Lynn Nadel; Oliver Hardt
Journal:  Neuropsychopharmacology       Date:  2010-09-22       Impact factor: 7.853

Review 4.  Glutamatergic model psychoses: prediction error, learning, and inference.

Authors:  Philip R Corlett; Garry D Honey; John H Krystal; Paul C Fletcher
Journal:  Neuropsychopharmacology       Date:  2010-09-22       Impact factor: 7.853

Review 5.  The 22q11.2 microdeletion: fifteen years of insights into the genetic and neural complexity of psychiatric disorders.

Authors:  Liam J Drew; Gregg W Crabtree; Sander Markx; Kimberly L Stark; Florence Chaverneff; Bin Xu; Jun Mukai; Karine Fenelon; Pei-Ken Hsu; Joseph A Gogos; Maria Karayiorgou
Journal:  Int J Dev Neurosci       Date:  2010-10-08       Impact factor: 2.457

Review 6.  Anticipating the future: automatic prediction failures in schizophrenia.

Authors:  Judith M Ford; Daniel H Mathalon
Journal:  Int J Psychophysiol       Date:  2011-09-28       Impact factor: 2.997

Review 7.  Structural coding versus free-energy predictive coding.

Authors:  Peter A van der Helm
Journal:  Psychon Bull Rev       Date:  2016-06

8.  A Perceptual Inference Mechanism for Hallucinations Linked to Striatal Dopamine.

Authors:  Clifford M Cassidy; Peter D Balsam; Jodi J Weinstein; Rachel J Rosengard; Mark Slifstein; Nathaniel D Daw; Anissa Abi-Dargham; Guillermo Horga
Journal:  Curr Biol       Date:  2018-02-02       Impact factor: 10.834

9.  Parsing components of auditory predictive coding in schizophrenia using a roving standard mismatch negativity paradigm.

Authors:  Amanda McCleery; Daniel H Mathalon; Jonathan K Wynn; Brian J Roach; Gerhard S Hellemann; Stephen R Marder; Michael F Green
Journal:  Psychol Med       Date:  2019-01-15       Impact factor: 7.723

10.  The anatomy of choice: active inference and agency.

Authors:  Karl Friston; Philipp Schwartenbeck; Thomas Fitzgerald; Michael Moutoussis; Timothy Behrens; Raymond J Dolan
Journal:  Front Hum Neurosci       Date:  2013-09-25       Impact factor: 3.169

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