Literature DB >> 1904969

Effects of oleic, arachidonic and 5,8,11,14-nonadecatetraenoic acids on lipid secretion and ketogenesis in perfused rat liver.

I Ikeda1, J Murakami, T Oka, M Sugano, H Yamada, S Shimizu, H Kawashima, Y Shinmen, T Amachi.   

Abstract

The effects of perfused oleic (18:1n-9), arachidonic (20:4n-6) and 5,8,11,14-nonadecatetraenoic (19:4n-5) acids on triglyceride and cholesterol secretion and ketone body production were studied in isolated rat liver. As compared to oleic and 19:4n-5 acids, both ketone body production and triglyceride secretion were significantly lowered when arachidonic acid was perfused. The concentration of triglyceride in the post-perfused liver was lower upon perfusion with arachidonic acid than upon perfusion with oleic acid or 19:4n-5 acid. Cholesterol secretion in the liver perfused with arachidonic acid or 19:4n-5 acid was significantly higher than with oleic acid. The concentration of cholesterol in the post-perfused liver was slightly but significantly higher with 19:4n-5 acid than with the other fatty acids. The results suggest that 19:4n-5 acid when compared with arachidonic acid affects lipid metabolism in liver differently.

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Year:  1991        PMID： 1904969     DOI： 10.1007/bf02544020

Source DB:  PubMed          Journal:  Lipids        ISSN： 0024-4201            Impact factor:   1.880


  20 in total

1.  Effects of ethyl arachidonate, cod-liver oil, and corn oil on the plasma-cholesterol level. A comparison in normal volunters.

Authors:  K J KINGSBURY; C AYLOTT; D M MORGAN; R EMMERSON
Journal:  Lancet       Date:  1961-04-08       Impact factor: 79.321

2.  Effects of several common long chain fatty acids on the properties and lipid composition of the very low density lipoprotein secreted by the perfused rat liver.

Authors:  H G Wilcow; G D Dunn; M Heimberg
Journal:  Biochim Biophys Acta       Date:  1975-07-22

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Authors:  W M SPERRY; M WEBB
Journal:  J Biol Chem       Date:  1950-11       Impact factor: 5.157

Review 4.  The role of dietary polyunsaturated fat in lowering blood cholesterol in man.

Authors:  R L Jackson; O D Taunton; J D Morrisett; A M Gotto
Journal:  Circ Res       Date:  1978-04       Impact factor: 17.367

5.  The regulation of hepatic triglyceride metabolism by free fatty acids.

Authors:  M Kohout; B Kohoutova; M Heimberg
Journal:  J Biol Chem       Date:  1971-08-25       Impact factor: 5.157

6.  The effect of palmitic and oleic acids on the properties and composition of the very low density lipoprotein secreted by the liver.

Authors:  M Heimberg; H G Wilcox
Journal:  J Biol Chem       Date:  1972-02-10       Impact factor: 5.157

7.  A colorimetric method for estimating serum triglycerides.

Authors:  M J Fletcher
Journal:  Clin Chim Acta       Date:  1968-11       Impact factor: 3.786

8.  Stimulation of hepatic cholesterol biosynthesis by fatty acids. Effects of oleate on cytoplasmic acetoacetyl-CoA thiolase, acetoacetyl-CoA synthetase and hydroxymethylglutaryl-CoA synthase.

Authors:  W H Salam; H G Wilcox; L M Cagen; M Heimberg
Journal:  Biochem J       Date:  1989-03-01       Impact factor: 3.857

9.  Pathway of alpha-linolenic acid through the mitochondrial outer membrane in the rat liver and influence on the rate of oxidation. Comparison with linoleic and oleic acids.

Authors:  P Clouet; I Niot; J Bézard
Journal:  Biochem J       Date:  1989-11-01       Impact factor: 3.857

10.  Fatty acid structural requirements for leukotriene biosynthesis.

Authors:  B A Jakschik; A R Sams; H Sprecher; P Needleman
Journal:  Prostaglandins       Date:  1980-08
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  1 in total

1.  Evidence that dietary arachidonic acid increases circulating triglycerides.

Authors:  J Whelan; M E Surette; B Li-Stiles; J W Bailey
Journal:  Lipids       Date:  1995-05       Impact factor: 1.880
  1 in total

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