Literature DB >> 19049594

Ketosis and brain handling of glutamate, glutamine, and GABA.

Marc Yudkoff1, Yevgeny Daikhin, Oksana Horyn, Ilana Nissim, Itzhak Nissim.   

Abstract

We hypothesize that one mechanism of the anti-epileptic effect of the ketogenic diet is to alter brain handling of glutamate. According to this formulation, in ketotic brain astrocyte metabolism is more active, resulting in enhanced conversion of glutamate to glutamine. This allows for: (a) more efficient removal of glutamate, the most important excitatory neurotransmitter; and (b) more efficient conversion of glutamine to GABA, the major inhibitory neurotransmitter.

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Year:  2008        PMID： 19049594      PMCID： PMC2722878          DOI： 10.1111/j.1528-1167.2008.01841.x

Source DB:  PubMed          Journal:  Epilepsia        ISSN： 0013-9580            Impact factor:   5.864


  15 in total

Review 1.  Excitotoxicity, apoptosis and neuropsychiatric disorders.

Authors:  John W Olney
Journal:  Curr Opin Pharmacol       Date:  2003-02       Impact factor: 5.547

Review 2.  Role of astrocytes in glutamate homeostasis: implications for excitotoxicity.

Authors:  Arne Schousboe; Helle S Waagepetersen
Journal:  Neurotox Res       Date:  2005-11       Impact factor: 3.911

Review 3.  The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer.

Authors:  Lasse K Bak; Arne Schousboe; Helle S Waagepetersen
Journal:  J Neurochem       Date:  2006-06-19       Impact factor: 5.372

4.  Response of brain amino acid metabolism to ketosis.

Authors:  Marc Yudkoff; Yevgeny Daikhin; Ilana Nissim; Oksana Horyn; Adam Lazarow; Bohdan Luhovyy; Suzanne Wehrli; Itzhak Nissim
Journal:  Neurochem Int       Date:  2005-07       Impact factor: 3.921

5.  Effects of ketone bodies on astrocyte amino acid metabolism.

Authors:  M Yudkoff; Y Daikhin; I Nissim; R Grunstein; I Nissim
Journal:  J Neurochem       Date:  1997-08       Impact factor: 5.372

Review 6.  Glutamine in the central nervous system: function and dysfunction.

Authors:  Jan Albrecht; Ursula Sonnewald; Helle S Waagepetersen; Arne Schousboe
Journal:  Front Biosci       Date:  2007-01-01

7.  Neuronal-glial interactions in rats fed a ketogenic diet.

Authors:  Torun Margareta Melø; Astrid Nehlig; Ursula Sonnewald
Journal:  Neurochem Int       Date:  2006-03-20       Impact factor: 3.921

8.  Short-term fasting, seizure control and brain amino acid metabolism.

Authors:  Marc Yudkoff; Yevgeny Daikhin; Ilana Nissim; Oksana Horyn; Bogdan Luhovyy; Adam Lazarow; Itzhak Nissim
Journal:  Neurochem Int       Date:  2006-02-28       Impact factor: 3.921

9.  Preferential utilization of acetate by astrocytes is attributable to transport.

Authors:  R A Waniewski; D L Martin
Journal:  J Neurosci       Date:  1998-07-15       Impact factor: 6.167

Review 10.  The ketogenic diet and brain metabolism of amino acids: relationship to the anticonvulsant effect.

Authors:  Marc Yudkoff; Yevgeny Daikhin; Torun Margareta Melø; Ilana Nissim; Ursula Sonnewald; Itzhak Nissim
Journal:  Annu Rev Nutr       Date:  2007       Impact factor: 11.848
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  30 in total

Review 1.  Ketone bodies in epilepsy.

Authors:  Melanie A McNally; Adam L Hartman
Journal:  J Neurochem       Date:  2012-02-07       Impact factor: 5.372

Review 2.  Mitochondrial energetics and therapeutics.

Authors:  Douglas C Wallace; Weiwei Fan; Vincent Procaccio
Journal:  Annu Rev Pathol       Date:  2010       Impact factor: 23.472

Review 3.  Ketogenic diet in migraine: rationale, findings and perspectives.

Authors:  Piero Barbanti; Luisa Fofi; Cinzia Aurilia; Gabriella Egeo; Massimiliano Caprio
Journal:  Neurol Sci       Date:  2017-05       Impact factor: 3.307

4.  Decreased carbon shunting from glucose toward oxidative metabolism in diet-induced ketotic rat brain.

Authors:  Yifan Zhang; Shenghui Zhang; Isaac Marin-Valencia; Michelle A Puchowicz
Journal:  J Neurochem       Date:  2014-11-10       Impact factor: 5.372

5.  Rapid adaptation of rat brain and liver metabolism to a ketogenic diet: an integrated study using (1)H- and (13)C-NMR spectroscopy.

Authors:  Maggie Roy; Marie-Christine Beauvieux; Jérôme Naulin; Dounia El Hamrani; Jean-Louis Gallis; Stephen C Cunnane; Anne-Karine Bouzier-Sore
Journal:  J Cereb Blood Flow Metab       Date:  2015-03-18       Impact factor: 6.200

6.  SLC6A1 Mutation and Ketogenic Diet in Epilepsy With Myoclonic-Atonic Seizures.

Authors:  Samantha Palmer; Meghan C Towne; Phillip L Pearl; Renee C Pelletier; Casie A Genetti; Jiahai Shi; Alan H Beggs; Pankaj B Agrawal; Catherine A Brownstein
Journal:  Pediatr Neurol       Date:  2016-07-28       Impact factor: 3.372

7.  Magnetic resonance assessment of the cerebral alterations associated with obesity development.

Authors:  Blanca Lizarbe; Basilio Campillo; Irene Guadilla; Pilar López-Larrubia; Sebastián Cerdán
Journal:  J Cereb Blood Flow Metab       Date:  2020-07-23       Impact factor: 6.200

8.  Novel aspect of ketone action: β-hydroxybutyrate increases brain synthesis of kynurenic acid in vitro.

Authors:  Iwona Chmiel-Perzyńska; Renata Kloc; Adam Perzyński; Sławomir Rudzki; Ewa M Urbańska
Journal:  Neurotox Res       Date:  2010-09-14       Impact factor: 3.911

Review 9.  Ketogenic diet, neuroprotection, and antiepileptogenesis.

Authors:  Madhuvika Murugan; Detlev Boison
Journal:  Epilepsy Res       Date:  2020-08-19       Impact factor: 3.045

Review 10.  Ketone body therapy: from the ketogenic diet to the oral administration of ketone ester.

Authors:  Sami A Hashim; Theodore B VanItallie
Journal:  J Lipid Res       Date:  2014-03-05       Impact factor: 5.922
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