Literature DB >> 16371316

Role of astrocytes in glutamate homeostasis: implications for excitotoxicity.

Arne Schousboe1, Helle S Waagepetersen.   

Abstract

Glutamate homeostasis in the brain is maintained by its well balanced release, uptake and metabolism. It appears that astrocytes play a prominent role in this context since they possess a very powerful battery of glutamate transporters. Thus, malfunction of astrocytic glutamate transporters will lead to an excessively high extracellular glutamate concentration which may result in neurodegeneration caused by the excitotoxic action of glutamate.

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Year:  2005        PMID： 16371316     DOI： 10.1007/BF03033975

Source DB:  PubMed          Journal:  Neurotox Res        ISSN： 1029-8428            Impact factor:   3.911


  41 in total

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Authors:  H T McMahon; D G Nicholls
Journal:  J Neurochem       Date:  1991-01       Impact factor: 5.372

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Journal:  Ann Neurol       Date:  1995-07       Impact factor: 10.422

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Journal:  Nature       Date:  1990-11-29       Impact factor: 49.962

4.  Differential expressions of glycine transporter 1 and three glutamate transporter mRNA in the hippocampus of gerbils with transient forebrain ischemia.

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Journal:  J Cereb Blood Flow Metab       Date:  1999-06       Impact factor: 6.200

5.  Analysis of glutamine accumulation in rat brain mitochondria in the presence of a glutamine uptake inhibitor, histidine, reveals glutamine pools with a distinct access to deamidation.

Authors:  E Ziemińska; W Hilgier; H S Waagepetersen; L Hertz; U Sonnewald; A Schousboe; J Albrecht
Journal:  Neurochem Res       Date:  2004-11       Impact factor: 3.996

6.  Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate.

Authors:  J D Rothstein; M Dykes-Hoberg; C A Pardo; L A Bristol; L Jin; R W Kuncl; Y Kanai; M A Hediger; Y Wang; J P Schielke; D F Welty
Journal:  Neuron       Date:  1996-03       Impact factor: 17.173

Review 7.  Glutamate uptake.

Authors:  N C Danbolt
Journal:  Prog Neurobiol       Date:  2001-09       Impact factor: 11.685

8.  Depolarization-induced release of [(3)H]D-aspartate from GABAergic neurons caused by reversal of glutamate transporters.

Authors:  J B Jensen; D S Pickering; A Schousboe
Journal:  Int J Dev Neurosci       Date:  2000 Apr-Jun       Impact factor: 2.457

9.  Multiple compartments with different metabolic characteristics are involved in biosynthesis of intracellular and released glutamine and citrate in astrocytes.

Authors:  H S Waagepetersen; U Sonnewald; O M Larsson; A Schousboe
Journal:  Glia       Date:  2001-09       Impact factor: 7.452

10.  Pyruvate carboxylase activity in primary cultures of astrocytes and neurons.

Authors:  A C Yu; J Drejer; L Hertz; A Schousboe
Journal:  J Neurochem       Date:  1983-11       Impact factor: 5.372
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  66 in total

1.  Metabotropic glutamate receptor-mediated signaling in neuroglia.

Authors:  David J Loane; Bogdan A Stoica; Alan I Faden
Journal:  Wiley Interdiscip Rev Membr Transp Signal       Date:  2012-01-11

2.  Characterization of the L-glutamate clearance pathways across the blood-brain barrier and the effect of astrocytes in an in vitro blood-brain barrier model.

Authors:  Hans Cc Helms; Blanca I Aldana; Simon Groth; Morten M Jensen; Helle S Waagepetersen; Carsten U Nielsen; Birger Brodin
Journal:  J Cereb Blood Flow Metab       Date:  2017-02-01       Impact factor: 6.200

Review 3.  Energy substrates to support glutamatergic and GABAergic synaptic function: role of glycogen, glucose and lactate.

Authors:  Arne Schousboe; Lasse K Bak; Helle M Sickmann; Ursula Sonnewald; Helle S Waagepetersen
Journal:  Neurotox Res       Date:  2007-12       Impact factor: 3.911

Review 4.  Astrocyte, the star avatar: redefined.

Authors:  Pankaj Seth; Nitin Koul
Journal:  J Biosci       Date:  2008-09       Impact factor: 1.826

Review 5.  Glutamate and glutamine: a review of in vivo MRS in the human brain.

Authors:  Saadallah Ramadan; Alexander Lin; Peter Stanwell
Journal:  NMR Biomed       Date:  2013-10-04       Impact factor: 4.044

Review 6.  Homocysteine and Gliotoxicity.

Authors:  Angela T S Wyse; Larissa Daniele Bobermin; Tiago Marcon Dos Santos; André Quincozes-Santos
Journal:  Neurotox Res       Date:  2021-03-30       Impact factor: 3.911

7.  Cellular changes underlying hyperoxia-induced delay of white matter development.

Authors:  Thomas Schmitz; Jonathan Ritter; Susanne Mueller; Ursula Felderhoff-Mueser; Li-Jin Chew; Vittorio Gallo
Journal:  J Neurosci       Date:  2011-03-16       Impact factor: 6.167

8.  Atorvastatin Promotes Cytotoxicity and Reduces Migration and Proliferation of Human A172 Glioma Cells.

Authors:  Karen A Oliveira; Tharine Dal-Cim; Flávia G Lopes; Fabiana K Ludka; Cláudia B Nedel; Carla I Tasca
Journal:  Mol Neurobiol       Date:  2017-02-08       Impact factor: 5.590

Review 9.  Mechanisms involved in the cerebrovascular dilator effects of N-methyl-d-aspartate in cerebral cortex.

Authors:  David W Busija; Ferenc Bari; Ferenc Domoki; Thomas Louis
Journal:  Brain Res Rev       Date:  2007-06-12

10.  Substrate competition studies demonstrate oxidative metabolism of glucose, glutamate, glutamine, lactate and 3-hydroxybutyrate in cortical astrocytes from rat brain.

Authors:  Mary C McKenna
Journal:  Neurochem Res       Date:  2012-10-19       Impact factor: 3.996
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