Literature DB >> 19047729

Structure and function of the LysR-type transcriptional regulator (LTTR) family proteins.

Sarah E Maddocks1, Petra C F Oyston2.   

Abstract

The LysR family of transcriptional regulators represents the most abundant type of transcriptional regulator in the prokaryotic kingdom. Members of this family have a conserved structure with an N-terminal DNA-binding helix-turn-helix motif and a C-terminal co-inducer-binding domain. Despite considerable conservation both structurally and functionally, LysR-type transcriptional regulators (LTTRs) regulate a diverse set of genes, including those involved in virulence, metabolism, quorum sensing and motility. Numerous structural and transcriptional studies of members of the LTTR family are helping to unravel a compelling paradigm that has evolved from the original observations and conclusions that were made about this family of transcriptional regulators.

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Year:  2008        PMID： 19047729     DOI： 10.1099/mic.0.2008/022772-0

Source DB:  PubMed          Journal:  Microbiology        ISSN： 1350-0872            Impact factor:   2.777


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