Literature DB >> 19047656

Pharmacokinetics and bioequivalence evaluation of two fixed-dose tablet formulations of dihydroartemisinin and piperaquine in Vietnamese subjects.

Nguyen Trong Chinh1, Nguyen Ngoc Quang, Nguyen Xuan Thanh, Bui Dai, Jason P Geue, Russell S Addison, Thomas Travers, Michael D Edstein.   

Abstract

The two fixed-dose combinations of dihydroartemisinin and piperaquine (Artekin and Arterakine) were found to be bioinequivalent in healthy Vietnamese subjects. However, because the peak plasma concentrations and areas under the concentration-time curves of dihydroartemisinin and piperaquine were only marginally different between the two formulations, similar therapeutic efficacies are expected in the treatment of malaria infections.

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Year:  2008        PMID： 19047656      PMCID： PMC2630617          DOI： 10.1128/AAC.00927-08

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  17 in total

1.  Pitfalls in estimating piperaquine elimination.

Authors:  Joel Tarning; Niklas Lindegårdh; Anna Annerberg; Thida Singtoroj; Nicholas P J Day; Michael Ashton; Nicholas J White
Journal:  Antimicrob Agents Chemother       Date:  2005-12       Impact factor: 5.191

2.  The influence of food on the pharmacokinetics of piperaquine in healthy Vietnamese volunteers.

Authors:  Trinh Ngoc Hai; Sofia Friberg Hietala; Nguyen Van Huong; Michael Ashton
Journal:  Acta Trop       Date:  2008-05-24       Impact factor: 3.112

3.  High throughput assay for the determination of piperaquine in plasma.

Authors:  N Lindegårdh; N J White; N P J Day
Journal:  J Pharm Biomed Anal       Date:  2005-09-15       Impact factor: 3.935

4.  Two fixed-dose artemisinin combinations for drug-resistant falciparum and vivax malaria in Papua, Indonesia: an open-label randomised comparison.

Authors:  A Ratcliff; H Siswantoro; E Kenangalem; R Maristela; R M Wuwung; F Laihad; E P Ebsworth; N M Anstey; E Tjitra; R N Price
Journal:  Lancet       Date:  2007-03-03       Impact factor: 79.321

5.  Phamacokinetics of a single oral dose of dihydroartemisinin in Vietnamese healthy volunteers.

Authors:  N H Le; K Na-Bangchang; T D Le; K A Thrinh; J Karbwang
Journal:  Southeast Asian J Trop Med Public Health       Date:  1999-03       Impact factor: 0.267

Review 6.  Artemisinin-based combination treatment of falciparum malaria.

Authors:  François Nosten; Nicholas J White
Journal:  Am J Trop Med Hyg       Date:  2007-12       Impact factor: 2.345

7.  Pharmacokinetics and efficacy of piperaquine and chloroquine in Melanesian children with uncomplicated malaria.

Authors:  Harin A Karunajeewa; Kenneth F Ilett; Ivo Mueller; Peter Siba; Irwin Law; Madhu Page-Sharp; Enmoore Lin; Jovitha Lammey; Kevin T Batty; Timothy M E Davis
Journal:  Antimicrob Agents Chemother       Date:  2007-10-29       Impact factor: 5.191

8.  Pharmacokinetics of the antimalarial drug piperaquine in healthy Vietnamese subjects.

Authors:  Trong Chinh Nguyen; Ngoc Quang Nguyen; Xuan Thanh Nguyen; Dai Bui; Thomas Travers; Michael D Edstein
Journal:  Am J Trop Med Hyg       Date:  2008-10       Impact factor: 2.345

9.  Safety, tolerability, and single- and multiple-dose pharmacokinetics of piperaquine phosphate in healthy subjects.

Authors:  Tausif Ahmed; Pradeep Sharma; Anirudh Gautam; Brijesh Varshney; Monica Kothari; Sanjeev Ganguly; Joerg J Moehrle; Jyoti Paliwal; Nilanjan Saha; Vijay Batra
Journal:  J Clin Pharmacol       Date:  2008-02       Impact factor: 3.126

10.  Population pharmacokinetics of piperaquine after two different treatment regimens with dihydroartemisinin-piperaquine in patients with Plasmodium falciparum malaria in Thailand.

Authors:  J Tarning; E A Ashley; N Lindegardh; K Stepniewska; L Phaiphun; N P J Day; R McGready; M Ashton; F Nosten; N J White
Journal:  Antimicrob Agents Chemother       Date:  2008-01-07       Impact factor: 5.191
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  14 in total

1.  Development, evaluation, and application of an in silico model for antimalarial drug treatment and failure.

Authors:  Katherine Winter; Ian M Hastings
Journal:  Antimicrob Agents Chemother       Date:  2011-05-02       Impact factor: 5.191

2.  Pharmacokinetics of dihydroartemisinin and piperaquine in pregnant and nonpregnant women with uncomplicated falciparum malaria.

Authors:  Marcus J Rijken; Rose McGready; Aung Phae Phyo; Niklas Lindegardh; Joel Tarning; Natthapon Laochan; Hla Hla Than; Oh Mu; Aye Kyi Win; Pratap Singhasivanon; Nicholas White; François Nosten
Journal:  Antimicrob Agents Chemother       Date:  2011-09-26       Impact factor: 5.191

3.  Pharmacokinetic comparison of two piperaquine-containing artemisinin combination therapies in Papua New Guinean children with uncomplicated malaria.

Authors:  Sam Salman; Madhu Page-Sharp; Kevin T Batty; Kaye Kose; Susan Griffin; Peter M Siba; Kenneth F Ilett; Ivo Mueller; Timothy M E Davis
Journal:  Antimicrob Agents Chemother       Date:  2012-04-02       Impact factor: 5.191

4.  Population pharmacokinetics of dihydroartemisinin and piperaquine in pregnant and nonpregnant women with uncomplicated malaria.

Authors:  Joel Tarning; Marcus J Rijken; Rose McGready; Aung Pyae Phyo; Warunee Hanpithakpong; Nicholas P J Day; Nicholas J White; François Nosten; Niklas Lindegardh
Journal:  Antimicrob Agents Chemother       Date:  2012-01-17       Impact factor: 5.191

5.  Altering Antimalarial Drug Regimens May Dramatically Enhance and Restore Drug Effectiveness.

Authors:  Katherine Kay; Eva Maria Hodel; Ian M Hastings
Journal:  Antimicrob Agents Chemother       Date:  2015-08-03       Impact factor: 5.191

6.  Pharmacokinetics and ex vivo pharmacodynamic antimalarial activity of dihydroartemisinin-piperaquine in patients with uncomplicated falciparum malaria in Vietnam.

Authors:  Dao Van Hoang Nguyen; Quoc Phuc Nguyen; Ngoa Dang Nguyen; Thuy Thi Thanh Le; The Duy Nguyen; Duy Ngoc Dinh; Thanh Xuan Nguyen; Dai Bui; Marina Chavchich; Michael D Edstein
Journal:  Antimicrob Agents Chemother       Date:  2009-06-15       Impact factor: 5.191

7.  Comparison of the Pharmacokinetics and Ex Vivo Antimalarial Activities of Artesunate-Amodiaquine and Artemisinin-Piperaquine in Healthy Volunteers for Preselection Malaria Therapy.

Authors:  Nguyen Ngoc Quang; Marina Chavchich; Chu Xuan Anh; Geoffrey W Birrell; Karin van Breda; Thomas Travers; Kerryn Rowcliffe; Michael D Edstein
Journal:  Am J Trop Med Hyg       Date:  2018-05-03       Impact factor: 2.345

8.  The efficacy and tolerability of artemisinin-piperaquine (Artequick®) versus artesunate-amodiaquine (Coarsucam™) for the treatment of uncomplicated Plasmodium falciparum malaria in south-central Vietnam.

Authors:  Nguyen Xuan Thanh; Trieu Nguyen Trung; Nguyen Chinh Phong; Huynh Hong Quang; Bui Dai; G Dennis Shanks; Marina Chavchich; Michael D Edstein
Journal:  Malar J       Date:  2012-06-28       Impact factor: 2.979

9.  Pharmacokinetics of piperaquine in pregnant women in Sudan with uncomplicated Plasmodium falciparum malaria.

Authors:  Ishag Adam; Joel Tarning; Niklas Lindegardh; Hyder Mahgoub; Rose McGready; François Nosten
Journal:  Am J Trop Med Hyg       Date:  2012-07       Impact factor: 2.345

Review 10.  Dihydroartemisinin-piperaquine for treating uncomplicated Plasmodium falciparum malaria.

Authors:  Babalwa Zani; Michael Gathu; Sarah Donegan; Piero L Olliaro; David Sinclair
Journal:  Cochrane Database Syst Rev       Date:  2014-01-20
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