Literature DB >> 19047377

Phage lysin LysK can be truncated to its CHAP domain and retain lytic activity against live antibiotic-resistant staphylococci.

Marianne Horgan1, Gary O'Flynn, Jennifer Garry, Jakki Cooney, Aidan Coffey, Gerald F Fitzgerald, R Paul Ross, Olivia McAuliffe.   

Abstract

A truncated derivative of the phage endolysin LysK containing only the CHAP (cysteine- and histidine-dependent amidohydrolase/peptidase) domain exhibited lytic activity against live clinical staphylococcal isolates, including methicillin-resistant Staphylococcus aureus. This is the first known report of a truncated phage lysin which retains high lytic activity against live staphylococcal cells.

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Year:  2008        PMID： 19047377      PMCID： PMC2632115          DOI： 10.1128/AEM.01831-08

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN： 0099-2240            Impact factor:   4.792


  29 in total

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4.  Rapid killing of Streptococcus pneumoniae with a bacteriophage cell wall hydrolase.

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7.  Phage lytic enzyme Cpl-1 as a novel antimicrobial for pneumococcal bacteremia.

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  49 in total

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2.  LysGH15, a novel bacteriophage lysin, protects a murine bacteremia model efficiently against lethal methicillin-resistant Staphylococcus aureus infection.

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Review 3.  Recombinant Endolysins as Potential Therapeutics against Antibiotic-Resistant Staphylococcus aureus: Current Status of Research and Novel Delivery Strategies.

Authors:  Hamed Haddad Kashani; Mathias Schmelcher; Hamed Sabzalipoor; Elahe Seyed Hosseini; Rezvan Moniri
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7.  Molecular aspects and comparative genomics of bacteriophage endolysins.

Authors:  Hugo Oliveira; Luís D R Melo; Sílvio B Santos; Franklin L Nóbrega; Eugénio C Ferreira; Nuno Cerca; Joana Azeredo; Leon D Kluskens
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8.  Enhanced staphylolytic activity of the Staphylococcus aureus bacteriophage vB_SauS-phiIPLA88 HydH5 virion-associated peptidoglycan hydrolase: fusions, deletions, and synergy with LysH5.

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10.  Synergism between a novel chimeric lysin and oxacillin protects against infection by methicillin-resistant Staphylococcus aureus.

Authors:  Anu Daniel; Chad Euler; Mattias Collin; Peter Chahales; Kenneth J Gorelick; Vincent A Fischetti
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